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MamPhEA specifications


Unique identifier OMICS_06543
Name MamPhEA
Alternative name Mammalian Phenotype Enrichment Analysis
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained Yes


  • person_outline Ben-Yang Liao

Publication for Mammalian Phenotype Enrichment Analysis

MamPhEA citations


Comparative Genomics Reveals Accelerated Evolution in Conserved Pathways during the Diversification of Anole Lizards

Genome Biol Evol
PMCID: 5798147
PMID: 29360978
DOI: 10.1093/gbe/evy013

[…] ed genes in each species to potential phenotypes, we examined statistically enriched GO categories as above, and tested for enrichment of mouse phenotypes using the gene IDs of the human orthologs in MamPhEA ().In anoles, limb morphology is related to locomotor differences and ecological niche adaptation among sympatric species (); therefore, we predict strong selective pressure on limb structure […]


Transcriptional regulation of endothelial cell behavior during sprouting angiogenesis

Nat Commun
PMCID: 5620061
PMID: 28959057
DOI: 10.1038/s41467-017-00738-7

[…] O terms associated with developmental processes, while upregulated genes, representing negative targets, were enriched for terms associated with mitosis, cell cycle regulation and metabolism (Fig. ). Mammalian phenotype enrichment analysis (MamPhEA) further demonstrated that MafB-regulated genes in retinal ECs were associated with phenotypes such as abnormal vasculature morphology, abnormal vascul […]


Evolutionary trajectories of snake genes and genomes revealed by comparative analyses of five pacer viper

Nat Commun
PMCID: 5059746
PMID: 27708285
DOI: 10.1038/ncomms13107

[…] ired PSGs with the free-ratio model dN/dS>1 at the focal lineage. For the identified RSGs and PSGs, we used their mouse orthologs' mutant phenotype information and performed enrichment analyses using MamPhEA. Then we grouped the enriched MP terms by different tissue types. […]


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MamPhEA institution(s)
Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan, China

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