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MANTIS specifications


Unique identifier OMICS_20470
Alternative name Microsatellite Analysis for Normal Tumor InStability
Software type Application/Script
Interface Command line interface
Restrictions to use None
Input format 6-column BED format
Operating system Unix/Linux
Programming languages Python
License GNU General Public License version 3.0
Computer skills Advanced
Stability Stable
NumPy, Pysam
Maintained Yes


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  • person_outline Sameek Roychowdhury <>

Publication for Microsatellite Analysis for Normal Tumor InStability

MANTIS in publication

PMCID: 5904988
PMID: 29665853
DOI: 10.1186/s40425-018-0341-y

[…] matched-normal dna sample for every specimen assayed because rare germline polymorphisms may be misinterpreted as positive microsatellite loci. likewise, some ngs-based msi-detection methods such as mantis [] and msisensor [] require a matched-normal sample. neither msiplus nor large panel ngs require matched-normal dna, which helps to simplify testing logistics and reduce cost. 2) […]

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MANTIS institution(s)
Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA; Department of Biomedical Informatics, The Ohio State University, Columbus, OH, USA; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA
MANTIS funding source(s)
Supported by American Cancer Society [grant number MRSG-12-194-01-TBG]; the Prostate Cancer Foundation; the National Human Genome Research Institute [grant number UM1HG006508]; the National Cancer Institute [grant number UH2CA202971]; the American Lung Association; Pelotonia; and Fore Cancer Research.

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