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MAPPP specifications

Information


Unique identifier OMICS_05743
Name MAPPP
Alternative names MHC-I Antigenic Peptide Processing Prediction, FRAGPREDICT
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained Yes

Maintainer


  • person_outline Hans Mollenkopf <>

Publication for MHC-I Antigenic Peptide Processing Prediction

MAPPP in pipelines

 (6)
2017
PMCID: 5450251
PMID: 28584450
DOI: 10.6026/97320630013094

[…] rank, 0.5 and 2 respectively was used in our study as in previous reports on other analytical approaches. strong binders alone were selected and used for further analysis., this was predicted using mappp (mhc-i antigenic peptide processing prediction) program []. the program generates a probability for the cleavage of each possible peptide from a protein by the proteasome in the cell […]

2017
PMCID: 5602290
PMID: 28943728
DOI: 10.6026/97320630013231

[…] amur) causing hfrs. the epitopes that bind to class i hla supertypes that is also cleaved only at the flanking regions by human proteasomes, binding to tap efficiently was identified by the programs mappp and tappred respectively. this study enabled the prediction of mhc class i binding t- cell epitopes from hantaviruses towards development of a designer peptide vaccine., all available complete […]

2017
PMCID: 5602290
PMID: 28943728
DOI: 10.6026/97320630013231

[…] (nonamer) was derived with the default threshold for strong binding and weak binding in terms of percent rank. strong binders alone were selected and used for further analysis as shown below:, mhc-i antigenic peptide processing prediction (mappp) program [] was used to predict proteasomal cleavage. the program generates a probability for the cleavage of each possible peptide from a protein […]

2011
PMCID: 3184218
PMID: 21551190
DOI: 10.1136/gut.2010.228403

[…] based on the genotype 1b donor sequence (genbank: af313916)., predicted epitopes were identified using a combination of different prediction programs (bimas, syfpeithi, jenner, propred 1, rankpep, mappp and net mhc). epitopes with the highest ranking were chosen (supplementary table 1 online). in order to generate cd8 t cell lines, we stimulated pbmcs with three of the predicted […]

2008
PMCID: 2569417
PMID: 18949050
DOI: 10.1371/journal.pone.0003525

[…] independent steps of the antigen processing pathway, and use a threshold on the summed score (e.g. mhc-pathway and netctl ), and those that eliminate epitope candidates at each step (e.g. epijen , mappp and the alternative implementation of mhc-pathway )., in this study we use the alternative implementation of the mhc-pathway model . we screen all possible peptide fragments of 14 amino acids […]


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MAPPP in publications

 (26)
PMCID: 5780746
PMID: 29363421
DOI: 10.1186/s12864-017-4328-8

[…] of hla binding peptides [–], and allow the prediction for a wide range of hla alleles. prediction in the context of hla supertypes is offered by a number of the tools, such as hotspot hunter [], mappp [], multipred2 [], pepvac [], and netmhc [], among others. earlier studies had elucidated putative t-cell epitopes of individual ebov proteins [–] by use of bioinformatics tools, […]

PMCID: 5773588
PMID: 29348555
DOI: 10.1038/s41598-018-19456-1

[…] dataset. netctl was selected to predict the ctl epitopes because of its higher prescient execution on all execution parameters as compared to the recently developed servers namely mhc-pathway, mappp, and epijen. all the salivary protein sequences were submitted in the fasta format to predict the ctl epitope at the threshold score of 0.75 (default). those epitopes having a combined score […]

PMCID: 5761135
PMID: 29316918
DOI: 10.1186/s12936-017-2144-x

[…] threshold of 3% and proteasome cleavage filter “on” was used for initial mhc class i epitope screening. subsequently, the maebl protein was re-screened using iedb [, ], netmhcpan [, ], bimas [, ], mappp [, ] and propredi []. all epitopes that were identified using all softwares were thus selected as those presenting the highest confidence., rankpep was also used to predicted mhc class ii […]

PMCID: 5712781
PMID: 29225429
DOI: 10.6026/97320630013366

[…] % rank (≤1), was used in our study. the epitopes of 9-mer and 10-mer lengths were derived. epitopes with binding affinity with the set threshold alone were selected and used for further analysis., mappp (mhc-i antigenic peptide processing prediction) program [] was used to predict proteasomal cleavage. the program generates a probability for the cleavage of each possible peptide from a protein […]

PMCID: 5666956
PMID: 28974013
DOI: 10.3390/ma10101150

[…] large deformation and failure problems., the research was supported by the research executive agency through the “training in multiscale analysis of multiphase particulate processes and systems” (t-mappp) project (fp7 people 2013 itn-g.a.n607453). the spanish ministry of economy and competitiveness (ministerio de economía y competitividad, mineco) through the project “desarrollo y validación de […]


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MAPPP institution(s)
University of Ulm, Department of Theoretical Computer Science, Ulm, Germany

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