Assists users in investigating cancer metabolism when data on metabolic measurements are not available. MaREA can be used to: (i) rank the reactions according to the variation in their activity observed between different phenotypes and/or experimental conditions, (ii) enrich the map of human metabolic routes with the variation observed in the Reaction Activity Score (RAS) of each reaction, and (iii) stratify samples according to their metabolic activity.
Department of Informatics, Systems and Communication, University of Milano-Bicocca, Milan, Italy; Department of Biotecnology and Bioscience, University of Milano-Bicocca, Milano, Italy; Candiolo Cancer Institute FPO IRCCS, Candiolo, Italy; Department of Oncology, University of Torino, Torino, Italy; SYSBIO Centre of Systems Biology, Milan, Italy
MaREA funding source(s)
Supported with FOE funds from the Italian Ministry of Education, Universities and Research to SYSBIO - within the Italian Roadmap for ESFRI Research Infrastructures; by grants from AIRC (investigator grant IG 16819 and 9970-2010 Special Program Molecular Clinical Oncology 5x1000), and by funds from the FLAG-ERA grant ITFoC.