MaxLink

[…] set of appropriate performance measures to compare state-of-the-art gene prioritization algorithms: three based on network diffusion, netrank and two implementations of random walk with restart, and maxlink that utilizes network neighborhood. our benchmark suite provides a systematic and objective way to compare the multitude of available and future gene prioritization tools, enabling […]

[…] typically predict candidate disease genes by measuring their network characteristics (correlation, connectivity, distance, etc.) to known disease genes from different perspectives, such as pinta, maxlink and genefriends., in this study, we presented a novel network analysis-based method named genepanda (gene prioritizing approach using network distance analysis) for prioritizing candidate […]

[…] for utilization of biological networks for improvement of identification (coverage) have been described, including analysis of overlaps, clique enrichment analysis, proteomics expansion pipeline, maxlink, and shortest-path methods (reviewed in []). the improvement of inconsistencies between different runs can be pursued using overlap analysis, direct group analysis, and network-based analysis […]

[…] we compare the recovery performance and functional insights from three distinct instances of ppin-based approaches, viz., proteomics expansion pipeline (pep), functional class scoring (fcs), and maxlink, in a test scenario of valproic acid (vpa)-treated mice. we find that the most comprehensive functional insights, as well as best non-detected protein recovery performance, are derived […]