MaxLink

[…] The relationship between TPR and FPR for the FPR range of particular interest in gene prioritization, i.e. typically up to an FPR of 0.1, is depicted in ROC curves(). Superior performance for MaxLink across all specificity ranges and ontologies compared to the other tools was apparent both from the ROC curves and the corresponding pAUCs for the FPR up to 0.02(). What also became apparent w […]

[…] to the core gene associated with the patient’s disease. We then compared the performance, interface and functions of the HGCS with those of two other state-of-the-art methods: (i) FunCoup, using the MaxLink interface, which ranks top interactors, and (ii) HumanNet, which ranks by top subnetworks [,]. In both FunCoup and HumanNet, we added the relevant core genes to the analyses, and chose the fir […]