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MBRole specifications


Unique identifier OMICS_04415
Name MBRole
Alternative name Metabolite Biological Role
Interface Web user interface
Restrictions to use None
Input data The main input provided by the user is the set of compounds of interest (e.g. those with significant concentration changes in a given condition).
Computer skills Basic
Stability Stable
Maintained Yes


  • person_outline Monica Chagoyen

Publication for Metabolite Biological Role

MBRole citations


Metabolome Integrated Analysis of High Temperature Response in Pinus radiata

Front Plant Sci
PMCID: 5914196
PMID: 29719546
DOI: 10.3389/fpls.2018.00485

[…] tions of R.Metabolomics pathways of each metabolite (Supplementary Table ) were searched against KEGG pathway maps (KEGG Mapper, ) and p-values of each metabolomics pathways (Supplementary Table ) in MBROLE 2.0 (). Heat mapping was carried out using the Manhattan distance method to group metabolites in different KEGG pathways with an MBROLE FDR correction of less than 0.05. Multivariate analysis o […]


Evaluation and comparison of bioinformatic tools for the enrichment analysis of metabolomics data

BMC Bioinformatics
PMCID: 5749025
PMID: 29291722
DOI: 10.1186/s12859-017-2006-0

[…] we only used serum/plasma biomarkers, results with other types of biological samples would have been similar. On one hand, metabolite disease sets are not up-to-date. For instance, MetaboAnalyst and MBRole (SMPDB and HMDB disease databases, respectively) base their searches of literature dated between 1975 and 2008, as stated in the outputs of these tools. Since 2008, advances in high-throughput […]


From chromatogram to analyte to metabolite. How to pick horses for courses from the massive web resources for mass spectral plant metabolomics

PMCID: 5499862
PMID: 28520864
DOI: 10.1093/gigascience/gix037

[…] sa Plant Pathway Viewer (KaPPA-View4) [], MapMan [], ProMeTra (which is integrated with MeltDB 2.0) [], Paintomics [], Visualization and Analysis of Networks Containing Experimental Data (VANTED) [], MBROLE [], and Integrated Molecular Pathway Level Analysis (IMPaLA) [] go 1 step further and integrate metabolomics processed data with other omics platforms, particularly transcriptomics, providing a […]


An integrative analysis of tissue specific transcriptomic and metabolomic responses to short term dietary methionine restriction in mice

PLoS One
PMCID: 5433721
PMID: 28520765
DOI: 10.1371/journal.pone.0177513

[…] ces between the control and MR groups via Welch’s test []. The level of false positives was controlled by FDR []. Pathway enrichment analysis from metabolite data in each tissue was conducted via the Metabolite Biological Role tool [] by querying KEGG pathways and using metabolites with a q-value ≤ 20%, as input. Significantly enriched pathways were visualized by the KEGG Mapper tool (http://www.g […]


Therapeutic efficacy of atypical antipsychotic drugs by targeting multiple stress related metabolic pathways

PMCID: 5534962
PMID: 28509906
DOI: 10.1038/tp.2017.94

[…] ion between different categories of biomarkers with a significance level of P<0.05. Moreover, the total list of metabolites was also analyzed using the bioinformatic tool Metabolites Biological Role (MBRole; http://csbg.cnb.csic.es/mbrole/) to identify over-represented or enriched biological pathways that could be putatively active (P<0.05 was considered significant).All statistical analyses were […]


Metabolic response induced by parasitic plant fungus interactions hinder amino sugar and nucleotide sugar metabolism in the host

Sci Rep
PMCID: 5124995
PMID: 27892480
DOI: 10.1038/srep37434

[…] way mapping, and enzymes that are intermediates of the integrated PPP () were researched in Kyoto Encyclopedia of Genes and Genomes (KEGG, http://www.genome.jp/kegg/). For pathway enrichment, we used MBrole (http://csbg.cnb.csic.es/mbrole/) with the KEGG pathway database. Scatter column plots using log-scaled data were derived from GraphPad Prism (version 5, GraphPad Software, USA), and the radar […]


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MBRole institution(s)
Computational Systems Biology Group, National Centre for Biotechnology (CNB-CSIC), Madrid, Spain
MBRole funding source(s)
Spanish Ministry for Science and Innovation (project number BIO2009-11966, in part)

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