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Protocols

MCG specifications

Information


Unique identifier OMICS_29832
Name MCG
Alternative name My Cancer Genome
Restrictions to use None
Community driven No
Data access Browse, Application programming interface
User data submission Not allowed
Maintained Yes

Documentation


Additional information


Previous version : https://www.mycancergenome.org/ https://meetinglibrary.asco.org/record/62158/abstract

MCG citations

 (7)
library_books

DGIdb 3.0: a redesign and expansion of the drug–gene interaction database

2017
Nucleic Acids Res
PMCID: 5888642
PMID: 29156001
DOI: 10.1093/nar/gkx1143

[…] matured, maintaining current representations of existing sources has become increasingly important relative to identifying new interaction sources. Curated updates of drug–gene interaction data from My Cancer Genome and the targeted and biologic therapies for non-small-cell lung cancer (TALC) have occurred, resulting in moderate increases in drug–gene interactions from these sources (,). To help […]

library_books

Proteogenomic integration reveals therapeutic targets in breast cancer xenografts

2017
Nat Commun
PMCID: 5379071
PMID: 28348404
DOI: 10.1038/ncomms14864

[…] version 3, assessed on 6/15/2015), Personalized Cancer Therapy (PCT, assessed on 3/15/2015), GDKD (Gene-Drug Knowledge Database, version 11.0, assessed on 4/10/2015), CancerDR (assessed on 2/6/2015), My Cancer Genome (assessed on 9/11/2014), and DrugBank (assessed on 9/21/2015). We curated the list based on evidence level and literature, as well as IC50 data when available. The final list used for […]

library_books

Major clinical research advances in gynecologic cancer in 2016: 10 year special edition

2017
PMCID: 5391398
PMID: 28382802
DOI: 10.3802/jgo.2017.28.e45

[…] approach could significantly enhance genomics-based personalized cancer therapy strategies.Similarly, Patel et al. [] compared 4 existing commercial web tools (Drug-Gene Interaction Database [DGidb], My Cancer Genome [MCG], Personalized Cancer Therapy [PCT], and cBioPortal) for best identifying therapeutic recommendations for a given genetic mutations in cancers. They listed the affected genes and […]

library_books

A variant by any name: quantifying annotation discordance across tools and clinical databases

2017
Genome Med
PMCID: 5267466
PMID: 28122645
DOI: 10.1186/s13073-016-0396-7

[…] sition, the standardized left-shifted VCF position should be at chr17:7578523 and right-shifted HGVS syntax as c.405_406insC or c.405dupC. In another example, a HER2 insertion variant is described in My Cancer Genome as c.2339_2340ins (with no insertion bases or transcript as reference) and G778_P780dup. The correct coding syntax by both SnpEff and VEP is c.2331_2339dup while the correct protein s […]

library_books

A Survey of Computational Tools to Analyze and Interpret Whole Exome Sequencing Data

2016
Int J Genomics
PMCID: 5192301
PMID: 28070503
DOI: 10.1155/2016/7983236

[…] The ability to link variants with actionable drug targets is an emerging research topic in precision medicine. Databases such as My Cancer Genome have provided the framework for these studies (https://www.mycancergenome.org/). My Cancer Genome provides a bridge between genomic data and clinical therapeutic treatments. Similarly […]

call_split

Association between proto oncogene mutations and clinicopathologic characteristics and overall survival in colorectal cancer in East Azerbaijan, Iran

2016
PMCID: 5153263
PMID: 27994469
DOI: 10.2147/OTT.S116373
call_split See protocol

[…] ecific exon were determined using “Database Nucleotide Collection Blast” in NCBI/BLAST. All sequence results (normal and tumor) were compared with the significant KRAS- and BRAF-gene mutations in the My Cancer Genome database of CRC, to identify mutations and the presence of new mutations. […]

Citations

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MCG institution(s)
Supported by Vanderbilt-Ingram Cancer Center, Edward P. Evans Foundation, Joyce Family Foundation Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation, T. J. Martell Foundation and Anonymous Foundation.

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