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mutation Cutoff Scanning Matrix mCSM

Online

Predicts the impact of single-point mutations on protein stability and protein–protein and protein–nucleic acid affinity. mCSM is an approach, which relies on graph-based signatures, for studying the impact of missense mutations in proteins. The software perceives residue environment density and depth implicitly, without relying on direct calculations or thresholds. It was applied to predict stability changes of mutations occurring in p53, demonstrating its applicability in a challenging disease scenario.

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mCSM classification

mCSM specifications

Interface:
Web user interface
Input format:
PDB
Stability:
Stable
Restrictions to use:
None
Computer skills:
Basic
Maintained:
Yes

Subtools

  • mCSM–NA

mCSM distribution

mCSM support

Maintainers

  • Douglas E. V. Pires <>
  • Tom Blundell <>

Additional information

http://structure.bioc.cam.ac.uk/mcsm_na

Credits

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Publications

Institution(s)

Department of Biochemistry, University of Cambridge, Cambridge, UK; ACRF Rational Drug Discovery
Centre and Biota Structural Biology Laboratory, St Vincents Institute of Medical Research, Fitzroy, VIC, Australia

Funding source(s)

Supported by Brazilian agency Conselho Nacional de Desenvolvimento Cientıfico e Tecnologico (CNPq), Brazil Victoria Fellowship from the Victorian Government and the Leslie (Les) J. Fleming Churchill Fellowship from the The Winston Churchill Memorial Trust and University of Cambridge and The Wellcome Trust.

Link to literature

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