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mutation Cutoff Scanning Matrix mCSM


Predicts the impact of single-point mutations on protein stability and protein–protein and protein–nucleic acid affinity. mCSM is an approach, which relies on graph-based signatures, for studying the impact of missense mutations in proteins. The software perceives residue environment density and depth implicitly, without relying on direct calculations or thresholds. It was applied to predict stability changes of mutations occurring in p53, demonstrating its applicability in a challenging disease scenario.

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mCSM classification

mCSM specifications

Web user interface
Input format:
Restrictions to use:
Computer skills:


  • mCSM–NA

mCSM distribution

mCSM support


  • Douglas E. V. Pires <>
  • Tom Blundell <>

Additional information


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Department of Biochemistry, University of Cambridge, Cambridge, UK; ACRF Rational Drug Discovery
Centre and Biota Structural Biology Laboratory, St Vincents Institute of Medical Research, Fitzroy, VIC, Australia

Funding source(s)

Supported by Brazilian agency Conselho Nacional de Desenvolvimento Cientıfico e Tecnologico (CNPq), Brazil Victoria Fellowship from the Victorian Government and the Leslie (Les) J. Fleming Churchill Fellowship from the The Winston Churchill Memorial Trust and University of Cambridge and The Wellcome Trust.

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