MDR-PDT statistics

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MDR-PDT specifications


Unique identifier OMICS_11222
Software type Application/Script
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux, Mac OS
Computer skills Advanced
Stability Stable
Maintained Yes


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  • person_outline Edin Martin <>

Publication for MDR-PDT

MDR-PDT in publications

PMCID: 4793893
PMID: 26108231
DOI: 10.1093/bib/bbv038

[…] limited extent by selecting a single matched pair from each family. to profit from extended informative pedigrees, mdr was merged with the genotype pedigree disequilibrium test (pdt) [] to form the mdr-pdt []. the genotype-pdt statistic is calculated for each multifactor cell and compared with a threshold, e.g. 0, for all possible d-factor combinations. if the test statistic is greater […]

PMCID: 3470565
PMID: 23071570
DOI: 10.1371/journal.pone.0046441

[…] et al. is a computational strategy to detect and characterize gene-gene interactions that may be associated with disease susceptibility . so far, mdr and its extensions such as gmdr, fam-mdr, mdr-pdt, emdr – have identified many interacting genetic variants underlying a wide variety of complex human diseases such as alzheimer's disease, asthma, atrial fibrillation, autism, bladder cancer, […]

PMCID: 2826406
PMID: 20186329
DOI: 10.1371/journal.pone.0009363

[…] compliment the mdr-pedigree disequilibrium test (pdt). a suggestion from previous work was to fit regression models post hoc to specifically evaluate the null hypothesis of no interaction for mdr or mdr-pdt models. we demonstrate with simulation that fitting a regression model on the same data as that analyzed by mdr or mdr-pdt is not a valid test of interaction. this is likely to be true […]

PMCID: 2731162
PMID: 19721717
DOI: 10.1371/journal.pone.0006875

[…] irish samples ( and )., to test whether genes interact to increase risk for schizophrenia, we examined gene-gene interaction by the multifactor dimensionality reduction pedigree disequilibrium test (mdr-pdt) and the multifactor dimensionality reduction method (mdr) for the ishdsf and iccss samples respectively. in both samples, 36 snps typed in the megf10 (10 markers), gulp1 (10 markers), […]

PMCID: 2412877
PMID: 18485205
DOI: 10.1186/1471-2105-9-238

[…] [], type ii diabetes [], coronary artery disease [], and autism []., there have been several notable extensions to the mdr method. multifactor dimensionality reduction pedigree disequilibrium test (mdr-pdt) was developed by martin et al. to examine multi-locus models in extended pedigree data []. mdr was extended to use a chi-square statistic as an alternative to prediction error/classification […]

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MDR-PDT institution(s)
Department of Medicine, Center for Human Genetics, Duke University Medical Center, Durham, NC, USA; Center for Human Genetic Research, Vanderbilt University Medical Center, Nashville, TN, USA; Computational Genetics Laboratory, Departments of Genetics, Biological Sciences, and Community and Family Medicine, Dartmouth Medical School, Lebanon, NH, USA; Department of Computer Science, University of New Hampshire, Durham, NH, USA

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