Meffil

Proceeds quality control, normalizes and performs epigenome-wide association studies (EWAS). Meffil permits to minimize computational memory requirements to 5% of that required by other R packages excluding increasing running time. It is based on a reimplementation of functional normalization method. The tool normalizes datasets distributed across physically different locations, avoiding sharing any biologically-based individual-level data. In addition, it can reduce heterogeneity in meta-analyses of EWAS.