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LAGLIDADG homing endonuclease (LHE) databases | Genome engineering

Meganucleases are important tools for genome engineering, providing an efficient way to generate DNA double-strand breaks at specific loci of interest. Numerous experimental efforts, ranging from in vivo selection to in silico modeling, have been made to re-engineer meganucleases to target relevant DNA sequences.

Source text:
(Zaslavskiy et al., 2014) Efficient design of meganucleases using a machine learning approach. BMC Bioinformatics.

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