Unlock your biological data
Meganucleases are important tools for genome engineering, providing an efficient way to generate DNA double-strand breaks at specific loci of interest. Numerous experimental efforts, ranging from in vivo selection to in silico modeling, have been made to re-engineer meganucleases to target relevant DNA sequences.
(Zaslavskiy et al., 2014) Efficient design of meganucleases using a machine learning approach. BMC Bioinformatics.