Meltdown specifications


Unique identifier OMICS_27851
Name Meltdown
Software type Application/Script
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux
Programming languages Python
Computer skills Advanced
Version 2.1.1
Stability Stable
Maintained Yes




No version available



  • person_outline Janet Newman

Publication for Meltdown

Meltdown citation


Multivalent Interactions of Human Primary Amine Oxidase with the V and C22 Domains of Sialic Acid Binding Immunoglobulin Like Lectin 9 Regulate Its Binding and Amine Oxidase Activity

PLoS One
PMCID: 5125647
PMID: 27893774
DOI: 10.1371/journal.pone.0166935
call_split See protocol

[…] icant increase in the signal (slope) corresponds to the melting of the protein. The analysis of the results and the melting temperature (Tm) estimation of thermal shift assay were calculated with the Meltdown program []. The program estimates the melting temperature in two ways: by using a quadratic fit to the data around the global minimum of the first derivative curve (this value is used as the […]

Meltdown institution(s)
Manufacturing Flagship, CSIRO, Parkville, VIC, Australia; Science and Engineering Faculty, Queensland University of Technology, Brisbane, QLD, Australia; Department of Physics, Wilkes University, Wilkes-Barre, PA, USA
Meltdown funding source(s)
Supported by the Victorian Life Sciences Computational Initiative, the Biomedical Research Victoria Undergraduate Research Opportunities Program (UROP), and CSIRO’s Transformational Biology program.

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