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MemGen specifications


Unique identifier OMICS_08567
Name MemGen
Interface Web user interface
Restrictions to use None
Input data One or more lipid structure files
Output data PDB file of the membrane
Computer skills Basic
Stability Stable
Maintained Yes


  • person_outline Jochen S. Hub <>

Publication for MemGen

MemGen citations


Lipids Shape the Electron Acceptor Binding Site of the Peripheral Membrane Protein Dihydroorotate Dehydrogenase

PMCID: 5856493
PMID: 29358052
DOI: 10.1016/j.chembiol.2017.12.012

[…] () projection approximation multiplied by an empirical factor 1.14 ()., the system was prepared by combining the dhodh starting structure with a hexagonal pe bilayer structure created with memgen () using 140 lipids per monolayer and the default area per lipid. pe parameters were taken from the stockholm lipids force field (, , ). after following the same equilibration procedure […]


Intratumoral CD40 activation and checkpoint blockade induces T cell mediated eradication of melanoma in the brain

PMCID: 5682289
PMID: 29129918
DOI: 10.1038/s41467-017-01572-7

[…] lifesciences). the mice were additionally monitored by their behavior and killed by an excessive hunched posture or the impairment of motoric capability., isf35 and control ad5 were provided by memgen, llc (houston, tx). mouse abs against ctla-4 (9h10), pd-1 (rmp1-14), pd-l1 (10f.9g2), cd4 (gk1.5), cd8 (2.43), nk (nk1.1), cd11b (m1/70), and agonist cd40 (fgk4.5) were purchased from bio x […]


Lipid II Independent Antimicrobial Mechanism of Nisin Depends On Its Crowding And Degree Of Oligomerization

PMCID: 5126574
PMID: 27897200
DOI: 10.1038/srep37908

[…] of model membrane were derived from peter tielman’s website ( the mixed bilayer consisting of 102 popc, 14 pope and 12 pops lipid molecules was reconstituted using memgen ( webtool. the bilayers were energy minimized first and equilibrated at 310 k temperature (nvt) and 1 atm pressure (npt) conditions. 40 ns of molecular dynamics (md) […]


The Lipid Bilayer Provides a Site for Cortisone Crystallization at High Cortisone Concentrations

PMCID: 4776104
PMID: 26936102
DOI: 10.1038/srep22425

[…] the quantum chemical calculations with the resp method. the topology file is available from the author (jsh) upon request., the lipid membrane simulation systems were generated with the web server memgen ( the patches corresponding to cortisone concentrations between 0 and 50% contained between 128 and 100 popc, between 0 and 100 cortisone, and between 4480 […]


The Molecular Basis of Polyunsaturated Fatty Acid Interactions with the Shaker Voltage Gated Potassium Channel

PMCID: 4709198
PMID: 26751683
DOI: 10.1371/journal.pcbi.1004704

[…] 500 ns. in addition, the mtsea+ modified systems were mutated back to cysteines after 500 ns of simulations and continued for 500 ns., two membrane patches were built using the membrane generator memgen [] with 24 lipids per leaflet. in each of the bilayer patches, dha or da, were inserted in each lipid leaflet and were set up as the described pufa system. the systems each contained ~12,000 […]


A Coarse Grained Model for a Lipid Membrane with Physiological Composition and Leaflet Asymmetry

PMCID: 4681583
PMID: 26659855
DOI: 10.1371/journal.pone.0144814

[…] of different lipid types in each leaflet based on a prior estimation of apl for the different lipid types. nearly all of the procedures currently available in literature, such as charmm-gui [], memgen [], insane (insert membrane) cg building tool []-to list a few; depend upon a priori assumption of the apl to choose the number of lipids in each leaflet. it is well known that the apl varies […]

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MemGen institution(s)
Georg-August-University Göttingen, Institute for Microbiology and Genetics, Justus-von-Liebig-Weg, Göttingen, Germany

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