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Citations per year

Number of citations per year for the bioinformatics software tool MemGen

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MemGen specifications


Unique identifier OMICS_08567
Name MemGen
Interface Web user interface
Restrictions to use None
Input data One or more lipid structure files
Output data PDB file of the membrane
Computer skills Basic
Stability Stable
Maintained Yes


  • person_outline Jochen S. Hub

Publication for MemGen

MemGen citations


Lipids Shape the Electron Acceptor Binding Site of the Peripheral Membrane Protein Dihydroorotate Dehydrogenase

Cell Chem Biol
PMCID: 5856493
PMID: 29358052
DOI: 10.1016/j.chembiol.2017.12.012
call_split See protocol

[…] The system was prepared by combining the DHODH starting structure with a hexagonal PE bilayer structure created with MemGen () using 140 lipids per monolayer and the default area per lipid. PE parameters were taken from the Stockholm lipids force field (, , ). After following the same equilibration procedure as for […]


Intratumoral CD40 activation and checkpoint blockade induces T cell mediated eradication of melanoma in the brain

Nat Commun
PMCID: 5682289
PMID: 29129918
DOI: 10.1038/s41467-017-01572-7

[…] ISF35 and control Ad5 were provided by Memgen, LLC (Houston, TX). Mouse Abs against CTLA-4 (9H10), PD-1 (RMP1-14), PD-L1 (10F.9G2), CD4 (GK1.5), CD8 (2.43), NK (NK1.1), CD11b (M1/70), and agonist CD40 (FGK4.5) were purchased from Bio X Cel […]


Lipid II Independent Antimicrobial Mechanism of Nisin Depends On Its Crowding And Degree Of Oligomerization

Sci Rep
PMCID: 5126574
PMID: 27897200
DOI: 10.1038/srep37908

[…] rdinates of model membrane were derived from Peter Tielman’s website ( The mixed bilayer consisting of 102 POPC, 14 POPE and 12 POPS lipid molecules was reconstituted using MemGen ( webtool. The bilayers were energy minimized first and equilibrated at 310 K temperature (NVT) and 1 atm pressure (NPT) conditions. 40 ns of Molecular Dynamics (MD) si […]


Convergent evolution of the arginine deiminase pathway: the ArcD and ArcE arginine/ornithine exchangers

PMCID: 5300872
PMID: 27804281
DOI: 10.1002/mbo3.412

[…] ) is part of a different superfamily, the Ion Transporter (IT) superfamily (Prakash, Cooper, Singhi, & Saier, ) emphasizing the fast evolutionary distance between the arcD and arcE gene families. The MemGen structural classification of membrane proteins (Lolkema & Slotboom, ; Lolkema & Slotboom, ; Lolkema & Slotboom, ) takes the next step in evolutionary distance by comparing hydropathy profiles o […]


The Lipid Bilayer Provides a Site for Cortisone Crystallization at High Cortisone Concentrations

Sci Rep
PMCID: 4776104
PMID: 26936102
DOI: 10.1038/srep22425

[…] d by the quantum chemical calculations with the RESP method. The topology file is available from the author (JSH) upon request.The lipid membrane simulation systems were generated with the web server MemGen ( The patches corresponding to cortisone concentrations between 0 and 50% contained between 128 and 100 POPC, between 0 and 100 cortisone, and between 4480 and […]


The Molecular Basis of Polyunsaturated Fatty Acid Interactions with the Shaker Voltage Gated Potassium Channel

PLoS Comput Biol
PMCID: 4709198
PMID: 26751683
DOI: 10.1371/journal.pcbi.1004704

[…] Two membrane patches were built using the membrane generator MemGen [] with 24 lipids per leaflet. In each of the bilayer patches, DHA or DA, were inserted in each lipid leaflet and were set up as the described PUFA system. The systems each contained ~12,000 at […]

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MemGen institution(s)
Georg-August-University Göttingen, Institute for Microbiology and Genetics, Justus-von-Liebig-Weg, Göttingen, Germany

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