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Mendel specifications


Unique identifier OMICS_09403
Name Mendel
Software type Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Computer skills Advanced
Version 16.0
Stability Stable
Maintained No


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Publications for Mendel

Mendel citations


An Extended Twin Pedigree Study of Neuroticism in the Netherlands Twin Register

Behav Genet
PMCID: 5752751
PMID: 29043520
DOI: 10.1007/s10519-017-9872-0

[…] ; jöreskog ). while these programs offer great flexibility in model specification, they are less well suited to the analysis of data from large and complex pedigrees. as an alternative, we used the mendel software package (lange et al. ) for genetic data analyses. we constructed and implemented an algorithm which took the ntr administrative database (boomsma et al. ) as input and gave […]


Prevalence and Penetrance of BRCA1 and BRCA2 Germline Mutations in Colombian Breast Cancer Patients

Sci Rep
PMCID: 5498630
PMID: 28680148
DOI: 10.1038/s41598-017-05056-y

[…] diagnosis from relatives of carriers of brca1/2 founder mutations (probands), and cumulative risks were estimated using breslow method. we also estimated the penetrance of brca1 mutations with the mendel package for statistical analyses, taking into account ascertainment by conditioning on proband diagnoses, . in short, a cox proportional hazards model was fitted to censored data on age […]


Characterization of Expression Quantitative Trait Loci in Pedigrees from Colombia and Costa Rica Ascertained for Bipolar Disorder

PLoS Genet
PMCID: 4866754
PMID: 27176483
DOI: 10.1371/journal.pgen.1006046

[…] different chromosomes., for each probe, we estimated the heritability of gene expression using two approaches: a variance components model relying on known family relationships as implemented in mendel [] and a variance decomposition based on observed genotypic similarities among individuals as implemented in gcta []. both analyses included age, sex, batch and peer factors as covariates. […]


A re formulation of generalized linear mixed models to fit family data in genetic association studies

Front Genet
PMCID: 4379931
PMID: 25873936
DOI: 10.3389/fgene.2015.00120

[…] data. for examples, vitesse implemented the well-known elston–stewart's peeling algorithm for computing the likelihood of pedigrees in linkage analysis (elston and stewart, ; o'connell and weeks, ). mendel can run pedigree analysis for quantitative traits (lange et al., ). sage sage () can be used for pedigree analysis of binary traits. based on the score statistics and generalized estimating […]


Comparison of Methods to Account for Relatedness in Genome Wide Association Studies with Family Based Data

PLoS Genet
PMCID: 4102448
PMID: 25033443
DOI: 10.1371/journal.pgen.1004445

[…] newly-proposed method differs from previously-proposed implementations. here we compare the performance of several lmm approaches (and software implementations, including emmax, genabel, fast-lmm, mendel, gemma and mmm) via their application to a genome-wide association study of visceral leishmaniasis in 348 brazilian families comprising 3626 individuals (1972 genotyped). the implementations […]


Fast genome wide pedigree quantitative trait loci analysis using MENDEL

BMC Proc
PMCID: 4143629
PMID: 25519348
DOI: 10.1186/1753-6561-8-S1-S93

[…] hard to compute, and current software for association mapping in pedigrees is prohibitively slow in processing dense marker maps. in a recent release of the comprehensive genetic analysis software mendel, we implemented an ultra-fast score test for association mapping with pedigree-based gwas or ngs study data. our implementation (a) works for random sample data, pedigree data, or a mix […]

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Mendel institution(s)
Department of Human Genetics; Department of Biomathematics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Department of Statistics; Department of Biostatistics, Fielding School of Public Health, UCLA, Los Angeles, CA, USA; Department of Statistics, North Carolina State University, Raleigh, NC, USA
Mendel funding source(s)
NIH grants MH059490, GM053275, GM103774 and HG006139

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