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Mendel specifications


Unique identifier OMICS_09403
Name Mendel
Software type Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Computer skills Advanced
Version 16.0
Stability Stable
Maintained No


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Publications for Mendel

Mendel citations


Computing Individual Risks Based on Family History in Genetic Disease in the Presence of Competing Risks

PMCID: 5700554
PMID: 29312466
DOI: 10.1155/2017/9193630

[…] from the sum-product of () in a suitable order. In that sense, it is very similar to the notion of cutset long used to compute likelihoods in complex pedigrees (see [], for a recent reference on the MENDEL package). But BP has the noticeable advantage to allow obtaining the full posterior distribution ℙ(X∣FH) for the same algorithmic complexity while likelihood-based approaches need to repeat man […]


An Extended Twin Pedigree Study of Neuroticism in the Netherlands Twin Register

Behav Genet
PMCID: 5752751
PMID: 29043520
DOI: 10.1007/s10519-017-9872-0

[…] . ; Jöreskog ). While these programs offer great flexibility in model specification, they are less well suited to the analysis of data from large and complex pedigrees. As an alternative, we used the Mendel software package (Lange et al. ) for genetic data analyses. We constructed and implemented an algorithm which took the NTR administrative database (Boomsma et al. ) as input and gave the larger […]


Subtypes of Native American ancestry and leading causes of death: Mapuche ancestry specific associations with gallbladder cancer risk in Chile

PLoS Genet
PMCID: 5444600
PMID: 28542165
DOI: 10.1371/journal.pgen.1006756
call_split See protocol

[…] e, estimated ancestry proportions tend to be similar within families, and consideration of actual incidence rates of gallbladder cancer may improve the accuracy of cancer-free survival estimates. The MENDEL software was used to take into account family relationships and real incidence rates of gallbladder cancer in Chile in validation analyses [, ].Data was analyzed using ADMIXTURE version 1.23, p […]


Using an Event History with Risk Free Model to Study the Genetics of Alcoholism

Sci Rep
PMCID: 5434012
PMID: 28512340
DOI: 10.1038/s41598-017-01791-4

[…] statistical models have been developed for simultaneously studying disease susceptibility and age of onset under a family-based genetic association study, although some software (e.g., PENETRANCE in MENDEL) can handle age of onset for penetrance estimation and the subsequent association analyses, and some other software (e.g., SEGREG in S.A.G.E.) can jointly analyze the susceptibility and age of […]


Characterization of Expression Quantitative Trait Loci in Pedigrees from Colombia and Costa Rica Ascertained for Bipolar Disorder

PLoS Genet
PMCID: 4866754
PMID: 27176483
DOI: 10.1371/journal.pgen.1006046

[…] of the discovered eSNPs, we constructed a multivariate linear mixed model relating expression to the genotypes at significant SNPs, local or distal. Using the variance components model implemented in Mendel, a fixed effect was estimated for age, sex, batch, the PEER factors, and each of the genetic variants, while a random effect was used to capture family structure. We then calculated the proport […]


Family based approaches: design, imputation, analysis, and beyond

BMC Genet
PMCID: 4895701
PMID: 26866700
DOI: 10.1186/s12863-015-0318-5
call_split See protocol

[…] R (minimum p value optimized nuisance parameter score test extended to relatives) [], GEMMA (genome-wide efficient mixed-model analysis) [], FARVAT (family-based rare variant association test) VC [], Mendel [], and implementations derived as part of GAW19 participation []. Additionally, 2 contributions used a 2-stage approach to speed up the computations [, ]. Each carried out initial analyses whi […]


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Mendel institution(s)
Department of Human Genetics; Department of Biomathematics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Department of Statistics; Department of Biostatistics, Fielding School of Public Health, UCLA, Los Angeles, CA, USA; Department of Statistics, North Carolina State University, Raleigh, NC, USA
Mendel funding source(s)
NIH grants MH059490, GM053275, GM103774 and HG006139

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