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MESSA specifications


Unique identifier OMICS_32403
Alternative name MEta Sever for Sequence Analysis
Interface Web user interface
Restrictions to use Academic or non-commercial use
Input data Some sequences or 3D structures of antibodies.
Input format FASTA,PDB
Programming languages Javascript, Python
License Academic Free License version 3.0
Computer skills Basic
Stability Stable
Maintained Yes


  • person_outline Nick Grishin

Publication for MEta Sever for Sequence Analysis

MESSA citations


Complete genome of Pieris rapae, a resilient alien, a cabbage pest, and a source of anti cancer proteins

PMCID: 5247789
PMID: 28163896
DOI: 10.5256/f1000research.10527.r19231

[…] roteins, i.e. the pierisins and nitrile-specifier proteins discussed above turned out to be unique for Pieris. We manually curated the sequences for proteins in these two groups and submitted them to MESSA to perform secondary structure and disordered region prediction, domain identification and 3D structure prediction. We aligned the pierisin sequences using MAFFT v7.237 and built their evolutio […]


Complete genomes of Hairstreak butterflies, their speciation, and nucleo mitochondrial incongruence

Sci Rep
PMCID: 4848470
PMID: 27120974
DOI: 10.1038/srep24863

[…] with any gene). GO terms with P-values lower than 0.01 were considered enriched. Significantly enriched GO terms (p < 0.01) were visualized in REVIGO. Important speciation hotspots were submitted to MESSA to perform secondary structure and disordered region prediction, domain identification and 3D structure prediction.Similarly, we identified the “speciation hotspots” for Pterourus glaucus and P. […]


nagZ Triggers Gonococcal Biofilm Disassembly

Sci Rep
PMCID: 4772129
PMID: 26927542
DOI: 10.1038/srep22372

[…] lture supernatants of Log-phase cells, but could readily detect its activity in the cell lysate. Bioinformatic programs to predict the cellular location of nagZ (Signal p4.0, PSORTb v3.0, PSLPred and MESSA) suggested a cytosolic or periplasmic location for NagZ (data not shown). Using both bacterial lysates and broth supernatants isolated from overnight cultures from FA1090∆nagZ, we were unable to […]


De Novo Genome Assembly Shows Genome Wide Similarity between Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense

PLoS One
PMCID: 4766357
PMID: 26910229
DOI: 10.1371/journal.pone.0147660

[…] , numbers of signal peptides, insertion scores, and numbers of homologs in the NCBI non-redundant protein database and in the RCSB protein database. We used Meta-Server for protein sequence analysis (MESSA) [] to predict their function. As four ORFs have close homologs in the Tbb genome (ORFs 4–7, ), we focused on the putative function of the remaining three ORFs for which no match in the Tbr/Tbg […]


Insights into the Interactions of Fasciola hepatica Cathepsin L3 with a Substrate and Potential Novel Inhibitors through In Silico Approaches

PLoS Negl Trop Dis
PMCID: 4433193
PMID: 25978322
DOI: 10.1371/journal.pntd.0003759

[…] The search for FhCL3 homologues (UniProt: Q9GRW6) [] was carried out in a non-redundant protein database using the PSI-BLAST at the NCBI server []. SAS [] and MESSA [] servers were additionally used against the Protein Data Bank (PDB) [] to retrieve the most suitable template. Automated multiple sequence alignment (MSA) was performed with MUSCLE v3.8.31 [] […]


Reduction and Expansion in Microsporidian Genome Evolution: New Insights from Comparative Genomics

Genome Biol Evol
PMCID: 3879972
PMID: 24259309
DOI: 10.1093/gbe/evt184

[…] sion of N. parisii CAP gene (NEPG_01805) increased at the time point in which spores were first observed (). Interestingly, the nonconserved regions are predicted to be intrinsically disordered using MESSA () (see Materials and Methods, ). Such regions cannot typically form stable tertiary structures in isolation and are often stabilized through interactions with other proteins (), allowing them t […]

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MESSA institution(s)
Departments of Biophysics and Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA
MESSA funding source(s)
Supported by National Institutes of Health (GM094575), the Citrus Research and Development Foundation (10-018-314) and the Welch Foundation (I-1505).

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