MetaboAnalyst protocols

View MetaboAnalyst computational protocol

MetaboAnalyst statistics

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Popular tool citations

chevron_left Metabolic network analysis Metabolite identification Metabolite identification Data normalization Data normalization Data integration Chemometric analysis Statistical analysis Clustering/Classification Statistical analysis Clustering chevron_right
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MetaboAnalyst specifications

Information


Unique identifier OMICS_02652
Name MetaboAnalyst
Alternative names Metabolomics Pathway Analysis, MetaboAnalystR
Interface Web user interface
Restrictions to use None
Computer skills Basic
Version 4.0
Stability Stable
Maintained Yes
Wikipedia https://en.wikipedia.org/wiki/MetaboAnalyst

Subtools


  • MetATT
  • MetPA
  • MSEA

Maintainers


  • person_outline David Wishart <>
  • person_outline Jianguo Xia <>
  • person_outline Jianguo Xia <>

Information


Unique identifier OMICS_02652
Name MetaboAnalyst
Alternative names Metabolomics Pathway Analysis, MetaboAnalystR
Software type Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Programming languages R
License GNU General Public License version 3.0
Computer skills Advanced
Version 1.0.1
Stability Stable
Maintained Yes

Subtools


  • MetATT
  • MetPA
  • MSEA

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Maintainers


  • person_outline David Wishart <>
  • person_outline Jianguo Xia <>
  • person_outline Jianguo Xia <>

Publications for MetaboAnalyst

MetaboAnalyst in pipelines

 (16)
2018
PMCID: 5797631
PMID: 29440987
DOI: 10.3389/fnins.2018.00032

[…] above noise level, automatic mass spectral deconvolution and peak detection at 5:1 (signal/noise)., peak intensity values normalized to tissue weight were used for statistical analysis in metaboanalyst 3.0 (xia and wishart, ). for normalization, values were log transformed and auto scaled. no filtering was applied given the relatively small number of features identified. compound […]

2018
PMCID: 5863097
PMID: 29425024
DOI: 10.1021/acs.analchem.7b04073

[…] data set is available upon request to the corresponding authors., statistical analysis, network/pathway analysis, and metabolite set enrichment analysis were performed in rstudio v0.99.486 and metaboanalyst 3.0. metabolites were identified with analytical standards and accurate mass matching in kegg and hmdb using custom dataset-wide and feature-specific deconvolution and identification […]

2018
PMCID: 5878833
PMID: 29628813
DOI: 10.1007/s11306-018-1352-x

[…] and technology, gaithersburg, md, usa), golmdb (kopka et al. ) and fiehnlib (kind et al. ) databases. annotated metabolites were normalized by internal standard and protein amount. finally, metaboanalyst 3.0 (xia et al. ) was used for statistical analysis., since s. cerevisiae has been used as a system for modeling mitochondrial diseases (goffeau et al. ; herrgard et al. ; lasserre et […]

2018
PMCID: 5918566
PMID: 29713366
DOI: 10.1186/s13007-018-0301-z

[…] were processed with r software for statistical computing using the xcms package for relative quantification []. partial least-squares (pls), heatmap construction and clustering were performed with metaboanalyst 3.0 []. the kruskal–wallis test (p < 0.05) was applied to show differences between conditions. for signal identification, marvis pathway software was used []. syringaresinol […]

2018
PMCID: 5940876
PMID: 29740146
DOI: 10.1038/s41598-018-25588-1

[…] to ensure reproducibility of retention indices and derivatization. data was processed, aligned, and analyzed using chromatof v. 4.51.6.0 with the statistical compare function (leco, st. joseph, mi), metaboanalyst, and in house software metabolyzer as previously described., cells were seeded at a density of 1,000 cells per well in 3, 96-well plastic tissue culture dishes per cell line on day 0. […]


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MetaboAnalyst in publications

 (864)
PMCID: 5955890
PMID: 29769578
DOI: 10.1038/s41598-018-25992-7

[…] test was performed. roc curves were built to test the sensibility and the specificity of the pool of the selected metabolites with the same software., metabolic pathways were generated by using metaboanalyst 3.0 (www.metaboanalyst.ca), a web server designed to obtain a comprehensive metabolomic data analysis, visualization and interpretation. with this approach, it was possible to correlate […]

PMCID: 5948901
PMID: 29751839
DOI: 10.1186/s12931-018-0800-5

[…] spss 18.0 software (spss inc., chicago, il, usa). a p value of less than 0.05 was considered significant. to identify the most significant metabolites involved in the pathophysiology of pah, we used metaboanalyst 3.0, a useful online website, to explore the potential metabolite and the involved pathway []. for further data analysis, partial least squares discriminant analysis (pls-da) was used […]

PMCID: 5941619
PMID: 29743087
DOI: 10.1186/s12944-018-0750-4

[…] encompassed diverse multivariate data analysis procedures such as principal components analysis (pca) and partial least squares-discriminant analysis (pls-da). such analyses were implemented using metaboanalyst 3.0 software (http://www.metaboanalyst.ca/). before carrying out pca and pls-da analyses, the peak intensity was controlled by a logarithmic transformation, and monitored by pareto […]

PMCID: 5940876
PMID: 29740146
DOI: 10.1038/s41598-018-25588-1

[…] coupled to a xevo® g2 qtof-ms using leucine enkephalin as lockspray® for accurate mass calibration. data was processed, aligned, and analyzed using masslynxtm (waters, milford, ma), xcms online, metaboanalyst, and r., internal standards (1 µm 4-nitrobenzoic acid) were added to culture media (500 μl) that was deproteinized as above and then evaporated in a speed-vac and transferred to a gc […]

PMCID: 5940703
PMID: 29740076
DOI: 10.1038/s41598-018-25552-z

[…] metabolites were identified (table ). then, we mapped these different metabolites into their biochemical pathways through metabolic enrichment and pathway analyses based on the kegg database and metaboanalyst. as shown in fig. , the significantly altered pathways were glycerophospholipid (gpl) metabolism, starch and sucrose metabolism, galactose metabolism, caffeine metabolism, and amino […]


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MetaboAnalyst institution(s)
Institute of Parasitology, McGill University, Montreal, QC, Canada; Department of Biological Sciences, University of Alberta, Edmonton, AB, Canada; Canadian Center for Computational Genomics, McGill University, Montreal, QC, Canada; Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA; Department of Human Genetics, McGill University, Montreal, QC, Canada; Department of Computing Science, University of Alberta, Edmonton, AB, Canada; Department of Animal Science, McGill University, Montreal, QC, Canada
MetaboAnalyst funding source(s)
Supported by McGill University; Natural Sciences and Engineering Research Council of Canada (NSERC), Canadian Institutes of Health Research (CIHR), Genome Canada, Canada Research Chairs Program (CRC).

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