The metabolome is defined as the quantitative complement of small molecular weight chemicals present in a biological system. The holistic study of the metabolome, defined as metabolomics, offers distinct advantages when compared to genomic, transcriptomic and proteomic investigations. However, the combined study of all functional levels and their complex interactions to provide a systems-wide view of biological organisation is beneficial. Metabolomics is increasingly being applied in post-genomic sciences to study biological systems including microorganisms, plants, mammals and the environment. Metabolomes are complex systems to study being composed of hundreds or thousands of metabolites with a wide range of physical and chemical properties such as hydrophobicity/hydrophilicity, volatility, molecular weight and size.
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