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Allows merging metabolic and signaling pathways reported in the Kyoto Encyclopaedia of Genes and Genomes (KEGG). MetaboSignal is a network-based approach designed to navigate through topological relationships between genes (signaling- or metabolic-genes) and metabolites, representing a powerful tool to investigate the genetic landscape of metabolic phenotypes. This approach is ideally suited to identify candidate genes in metabotype-Quantitative-Trait Locus (QTL) or to identify biological pathways affected in transgenic models. This approach is ideally suited to identify candidate genes in metabotype-QTL studies (e.g. trans-acting associations), or to identify biological pathways affected in transgenic models.

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MetaboSignal classification

MetaboSignal specifications

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Command line interface
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Unix/Linux, Mac OS, Windows
GNU General Public License version 3.0

MetaboSignal distribution


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MetaboSignal support



  • Marc-Emmanuel Dumas <>


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Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK; Sorbonne Universities, University Pierre & Marie Curie, University Paris Descartes, Sorbonne Paris Cité, INSERMUMR_S 1138, Cordeliers Research Centre, Paris, France

Funding source(s)

This work was supported by Medical Research Council Doctoral Training Centre PhD scholarship (MR/ K501281/1), Imperial College PhD-scholarship (EP/M506345/1), La Caixa studentship, Portuguese Foundation for Science and Technology (SFRH/BD/52036/2012), the European Commission (FGENTCARD, LSHG-CT-2006-037683, EURATRANS, HEALTH-F4- 2010-241504, METACARDIS, HEALTH-F4-2012-305312).

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