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Metadisorder specifications


Unique identifier OMICS_03634
Name Metadisorder
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained Yes


  • person_outline Lukasz Kozlowski

Publication for Metadisorder

Metadisorder citations


Polymorphism in merozoite surface protein 7E of Plasmodium vivax in Thailand: Natural selection related to protein secondary structure

PLoS One
PMCID: 5931635
PMID: 29718980
DOI: 10.1371/journal.pone.0196765

[…] mains. Four α-helices were located in the N-terminal and the remaining 6 α-helices at the C-terminal (). The majority of the non-helical regions seem to contain random coil motifs. Analysis using the MetaDisorder series implemented in the GeneSilico Metadisorder service has identified 3 intrinsically unstructured or disordered regions that span codons 27–36, 46–102 and 121–241, referred here as do […]


Functional domains of the FSHD associated DUX4 protein

PMCID: 5936065
PMID: 29618456
DOI: 10.1242/bio.033977

[…] et-based prediction sites to identify likely structural features of the endogenous DUX4-FL protein. Sites that we consulted include RaptorX at () (A); MetaDisorder at (); Phyre2 at (); Robetta at (); and the Eukaryotic Linear Motif Resource at http://e […]


Bioinformatic Analysis Reveals Conservation of Intrinsic Disorder in the Linker Sequences of Prokaryotic Dual family Immunophilin Chaperones

Comput Struct Biotechnol J
PMCID: 5852385
PMID: 29552333
DOI: 10.1016/j.csbj.2017.12.002
call_split See protocol

[…] we subjected a single CFBP sequence to disorder prediction by multiple programs, and the PrDOS results agreed with essentially all of them, including several meta-predictors (data not shown), such as MetaDisorder, which compares nearly two dozen different methods [], and PONDR-FIT, which combines five []. For routine analysis, the PrDOS results were downloaded as CSV (comma-separated values) files […]


Structural disorder and induced folding within two cereal, ABA stress and ripening (ASR) proteins

Sci Rep
PMCID: 5686140
PMID: 29138428
DOI: 10.1038/s41598-017-15299-4

[…] nce accession numbers are KX660743 for HvASR1 and KX660744 for TtASR1. Disordered regions within HvASR1 and TtASR1 were identified using the MeDor (, and the Genesilico MetaDisorder ( metaservers for the prediction of disorder. These metaservers collect disorder and secondary structure predictions from servers […]


Conjecture Regarding Posttranslational Modifications to the Arabidopsis Type I Proton Pumping Pyrophosphatase (AVP1)

Front Plant Sci
PMCID: 5601048
PMID: 28955362
DOI: 10.3389/fpls.2017.01572

[…] Local prediction of Intrinsically Unstructured Protein Regions (protein disorder) from amino acid sequences (). Method: MetaDisorderMD2. Server at: […]


Conformational plasticity and evolutionary analysis of the myotilin tandem Ig domains

Sci Rep
PMCID: 5479843
PMID: 28638118
DOI: 10.1038/s41598-017-03323-6

[…] e/). Conservation scores for each myotilin residue in the multiple sequence alignment (MSA) were calculated using the Scorecons server. Disorder tendency prediction was performed using the GeneSilico MetaDisorder server.ConSurf-DB was used for presentation of evolutionary conservation profiles of myotilin Ig domains. Pre-calculated MSA for Ig1 consisted of 301 homologues and 152 homologues for Ig2 […]


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Metadisorder institution(s)
Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular and Cell Biology, Warsaw, Poland

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