Incorporates curated information on biological effects of small molecule compounds. MetaDrug predictions rely on manually curated information about compound targets, metabolic fate, ADME properties, and therapeutic and side effects. Nearly 6,000 human proteins are covered by compound information. Every target in MetaDrug comes with protein interactions to explore biological pathways affected by the user’s compounds and network neighborhood of drug targets. OMICs data analysis capabilities provide an additional approach for solving the compound’s mechanisms of action, discovering drug efficacy biomarkers, and corroborating the hypotheses generated by classical structure-based methods.