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METASOFT specifications


Unique identifier OMICS_27440
Software type Application/Script
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux
Computer skills Advanced
Version 2.0.1
Stability Stable
Maintained Yes




No version available


  • person_outline Eleazar Eskin
  • person_outline Buhm Han
  • person_outline Eun Yong Kang

Publication for METASOFT

METASOFT citations


Elucidating the genetic architecture of reproductive ageing in the Japanese population

Nat Commun
PMCID: 5958096
PMID: 29773799
DOI: 10.1038/s41467-018-04398-z
call_split See protocol

[…] a applied to BBJ women. This analysis was performed using a linear mixed model implemented in BOLT. Trans-ethnic meta-analysis was performed using Han and Eskin’s Random Effects model, implemented in Metasoft. […]


Predictors of poor outcome in patients with pulmonary arterial hypertension: A single center study

PLoS One
PMCID: 5912712
PMID: 29684090
DOI: 10.1371/journal.pone.0193245

[…] oxide output (VCO2), expiratory gas concentrations throughout the respiratory cycle, and minute ventilation (VE) were measured continuously on a breath-by-breath basis using the Cortex equipment with Metasoft 3.9 software (Cortex Biophisik Gmbh, Germany). The peak oxygen consumption (VO2peak) was derived from the maximum average value during 30 seconds at maximal endurance. The anaerobic threshold […]


Epigenome wide association study of metabolic syndrome in African American adults

Clin Epigenetics
PMCID: 5891946
PMID: 29643945
DOI: 10.1186/s13148-018-0483-2

[…] Top results from the HyperGEN and REGARDS studies were meta-analyzed using random effects models implemented in the METASOFT program based on the method of Han and Eskin [] to ensure validity in the presence of effect heterogeneity. […]


Effects of a School Based Sports Program on Physical Fitness, Physical Activity, and Cardiometabolic Health in Youth With Physical Disabilities: Data From the Sport 2 Stay Fit Study

PMCID: 5879083
PMID: 29632853
DOI: 10.3389/fped.2018.00075

[…] level of mobility as described previously (). During the SRT, a calibrated mixing chamber Cortex Metamax 3X (Samcon bvba, Melle, Belgium) was used to measure VO2 peak. Metabolic stress test software (Metasoft Studio) was used to measure oxygen uptake (VO2), carbon dioxide production (VCO2), peak heart rate (HR), and respiratory exchange ratio (RER) = (VCO2/VO2). Each test lasted until exhaustion. […]


Retinal Vessel Diameters and Physical Activity in Patients With Mild to Moderate Rheumatic Disease Without Cardiovascular Comorbidities

Front Physiol
PMCID: 5854847
PMID: 29593551
DOI: 10.3389/fphys.2018.00176
call_split See protocol

[…] a test duration of 8–12 min as recommended by American College of Sports Medicine (). Ventilatory parameters were measured using a calibrated breath-by-breath spiroergometry solution (Metalyzer® 3B, MetaSoft® software from CORTEX Biophysik GmbH, Leipzig, Germany). […]


Investigation of cardiopulmonary exercise testing using a dynamic leg press and comparison with a cycle ergometer

PMCID: 5815210
PMID: 29468072
DOI: 10.1186/s13102-018-0095-3

[…] monary monitoring system (Metamax 3B, Cortex Biophysik GmbH, Germany; Fig. ). Analysis of the cardiopulmonary data was done using the proprietary software associated with the breath-by-breath system (Metasoft, version 3.9.9 SR5). Pressure, volume and gas concentrations were calibrated prior to each test according the manufacturer’s instructions: pressure was calibrated using a certified atmospheri […]


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METASOFT institution(s)
Department of Computer Science, University of California Los Angeles, Los Angeles, CA, USA; Department of Human Genetics, University of California Los Angeles, Los Angeles, CA, USA
METASOFT funding source(s)
Supported by National Science Foundation grants 0513612, 0731455, 0729049, 0916676, and 1065276 and by National Institutes of Health grants K25-HL080079, U01-DA024417, P01-HL30568, and PO1-HL28481, the Samsung Scholarship, in part by the University of California Los Angeles subcontract of contract N01-ES-45530 from the National Toxicology Program and National Institute of Environmental Health Sciences to Perlegen Sciences.

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