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MethHC specifications


Unique identifier OMICS_29628
Name MethHC
Restrictions to use None
Community driven No
Data access Browse
User data submission Not allowed
Version 1.0.3
Maintained Yes


  • Primates
    • Homo sapiens


  • person_outline Hsien-Da Huang

Additional information

Publication for MethHC

MethHC citations


SRARP and HSPB7 are epigenetically regulated gene pairs that function as tumor suppressors and predict clinical outcome in malignancies

Mol Oncol
PMCID: 5928383
PMID: 29577611
DOI: 10.1002/1878-0261.12195

[…] tute ( (Grossman et al., ). Gene expression data were derived from RNA sequencing (RNA‐seq) RPKM (reads per kilobase per million mapped reads) values in TCGA Data Portal using MethHC 1.0.3 ( Median expression levels were obtained for tumor and normal samples in each dataset. Next, differential gene expression values were calculat […]


Nc886 is epigenetically repressed in prostate cancer and acts as a tumor suppressor through the inhibition of cell growth

BMC Cancer
PMCID: 5797390
PMID: 29394925
DOI: 10.1186/s12885-018-4049-7

[…] The TCGA-PRAD data was downloaded from the TCGA portal ( [] and the Methhc database ( []. This dataset includes the RNA-Seq expression values of 50 matched normal and tumor tissue and additional unmatched normal and tumor sa […]


HOXC8 regulates self renewal, differentiation and transformation of breast cancer stem cells

Mol Cancer
PMCID: 5312582
PMID: 28202042
DOI: 10.1186/s12943-017-0605-z

[…] , ]. Expression analysis of HOXC8 in the METABRIC dataset [, ] was also obtained from the OASIS portal. Methylation analysis of the TCGA dataset was performed by using the UCSC Cancer Browser and the MethHC browser ( [].All data are expressed as mean ± standard deviation. Comparisons between two samples were done using Student’s t-test. One-way or Two-wa […]


Maternal Smoking during Pregnancy and DNA Methylation in Children at Age 5.5 Years: Epigenome Wide Analysis in the European Childhood Obesity Project (CHOP) Study

PLoS One
PMCID: 4865176
PMID: 27171005
DOI: 10.1371/journal.pone.0155554

[…] lood (GM12878, K562) and endothelial (HUVEC) cell lines []. Associations between transcription and DNA methylation at CpGs along the MYO1G locus was retrieved from the pan-cancer methylation database MethHC []. General and tobacco-related expression pattern of CNTNAP2 and FRMD4A was assessed using Human Proteome Map [] and Gene Expression Atlas at the European Bioinformatics Institute [], respecti […]


Epigenetic modification of TLR4 promotes activation of NF κB by regulating methyl CpG binding domain protein 2 and Sp1 in gastric cancer

PMCID: 4826199
PMID: 26675260
DOI: 10.18632/oncotarget.6549

[…] using qPCR and reverse transcription-PCR. Interestingly, TLR4 mRNA expression was overwhelmingly low levels in all gastric cancer cell lines and high level in SNU-668, AGS, and SNU-216 (Figure ). The MethHC database ( shows that TLR4 is expressed through promoter demethylation, but is occasionally downregulated by hypermethylation in gastric cancer tissues. This in si […]


The 2015 Nucleic Acids Research Database Issue and Molecular Biology Database Collection

Nucleic Acids Res
PMCID: 4383995
PMID: 25593347
DOI: 10.1093/nar/gku1241

[…] bases focus on diverse aspects of cancers, from identification of candidate genes in mice [Mouse Tumor Biology Database and the Candidate Cancer Gene Database, (,)] via the impact of DNA methylation (MethHC) or copy number variation (ArrayMap) in cancer cells, to the consequences of mutations at the protein sequence or structural level (Cancer Mutant Proteome Database, Cancer3D) (–).While many dat […]


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MethHC institution(s)
Department of Biological Science and Technology, National Chiao Tung University, Hsin-Chu, Taiwan; Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsin-Chu, Taiwan; Department of Obstetrics and Gynecology, Hsinchu Mackay Memorial Hospital, Hsin-Chu, Taiwan; Mackay Medicine, Nursing and Management College, Taipei, Taiwan; Department of Medicine, Mackay Medical College, New Taipei City, Taiwan; Center for Bioinformatics Research, National Chiao Tung University, Hsin-Chu, Taiwan; Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, Taiwan
MethHC funding source(s)
Supported by the Ministry of Science and Technology of the Republic of China [NSC 101–2311-B-009–005-MY3 and NSC 102– 2627-B-009–001]; the UST-UCSD International Center of Excellence in Advanced Bio-engineering sponsored by the Taiwan Ministry of Science and Technology I-RiCE Program [NSC 102–2911-I-009–101]; Veterans General Hospitals and University System of Taiwan (VGHUST) Joint Research Program [VGHUST103-G5–1–2] and MOE ATU.

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