Performs analyses of array-based DNA methylation data. MethLAB is a graphical user interface (GUI) package. For each cytosine–phosphate–guanine (CpG) site, the software models methylation as a function of a categorical or continuous phenotype and other covariates. This package can incorporate both continuous and categorical covariates, as well as fixed or random batch or chip effects. It has been designed to optimize memory use during analyses.