Methylator specifications

Information


Unique identifier OMICS_09960
Name Methylator
Interface Web user interface
Restrictions to use None
Input data A nucleotide sequence in one of the standard formats such as GenBank, EMBL, GCG, or plain format.
Output data After the analysis the results are shown in user-friendly format. The methylated cytosines are shown in bolder and red color as compare to rest of the cytosines.
Computer skills Basic
Stability No
Maintained No

Taxon


  • Primates
    • Homo sapiens

Publication for Methylator

Methylator in publications

 (846)
PMCID: 5958058
PMID: 29773832
DOI: 10.1038/s41467-018-04383-6

[…] human genome. data were then adjusted for color balance bias and normalized between samples using the ssn (shift and scaling normalization) method using the lumi package functions. the cpg island methylator phenotype (cimp) index was estimated by adapting the approach by toyota et al.. in brief, cpg islands found to be unmethylated ( < 20% β-value) in all 25 normal pancreatic samples […]

PMCID: 5954004
DOI: 10.1186/s41181-018-0041-4

[…] taking bearing in mind that we did not have a drug legislation that did also cover radiopharmaceuticals., aim: university institute of positron emission tomography skopje is equipped with the methylator ii (comecer spa. former veenstra instruments bv.), a module designed for the production of high specific activity methyliodide ([11c]ch3i) and/or methyl triflate ([11c]ch3oso2cf3) […]

PMCID: 5957310
PMID: 29742878
DOI: 10.3340/jkns.2018.0003

[…] island hypermethylation and global dna hypomethylation. a higher extent of cpg island methylation was found in pf-epn-a compared to that in pf-epn-b []. therefore, pf-epn-a referred to cpg island methylator phenotype (cimp)-positive epns and pfepn-b referred to cimp-negative epns. for defining highrisk pf-epn-a from low-risk pf-epn-b, immunohistochemical staining of histone h3 lysine 27 […]

PMCID: 5919009
PMID: 29694444
DOI: 10.1371/journal.pone.0196233

[…] is also more prevalent in older patients, in tumors originating from serrated lesions, tumors with extensive hypermethylation of cpg islands in tumor suppressor gene promoters (i.e., the cpg island methylator phenotype (cimp)), as well as tumors with microsatellite instability (msi) caused by malfunctioning dna mismatch repair [, ]., crc subtypes defined by kras and braf mutation status […]

PMCID: 5902988
PMID: 29661177
DOI: 10.1186/s12885-018-4337-2

[…] and copy number changes were significantly associated with multiple molecular and clinicopathological features of crc including microsatellite instability (msi), mlh1 silencing, cpg island methylator phenotype, hyper-mutation status, gender, presence of synchronous adenomas, and histological type (p < 0.05). patients with lower zg16 gene expression showed shorter progression-free […]


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Methylator institution(s)
Laboratory of Immunobiology and Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA

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