MetSign statistics

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Citations per year

Number of citations per year for the bioinformatics software tool MetSign

Tool usage distribution map

This map represents all the scientific publications referring to MetSign per scientific context
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MetSign specifications


Unique identifier OMICS_07857
Name MetSign
Software type Pipeline/Workflow
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Programming languages MATLAB
Computer skills Advanced
Stability Stable
Maintained Yes


No version available


  • person_outline Xiang Zhang

Publications for MetSign

MetSign citations


Integration of flux measurements to resolve changes in anabolic and catabolic metabolism in cardiac myocytes

PMCID: 5545928
PMID: 28706006
DOI: 10.1042/BCJ20170474

[…] mass lists into a spreadsheet file using Qual-Browser 2.0 (Thermo Electron). Isotopologue peak deconvolution, assignment, natural isotope abundance stripping, and quantification were performed using MetSign software, as described previously [,]. […]


From chromatogram to analyte to metabolite. How to pick horses for courses from the massive web resources for mass spectral plant metabolomics

PMCID: 5499862
PMID: 28520864
DOI: 10.1093/gigascience/gix037

[…] ly, flexible, and extendable software constantly updated and with a set of modules covering most steps of LC-MS processing and data analysis workflow, including several option of visualization tools. MetSign [] is a MATLAB package providing tools for spectra deconvolution, metabolite putative assignment by matching m/z, and peak isotopic distribution against its own database, peak list alignment, […]


Data Dependent Peak Model Based Spectrum Deconvolution for Analysis of High Resolution LC MS Data

Anal Chem
PMCID: 3982975
PMID: 24533635
DOI: 10.1021/ac403803a

[…] After construction of the XICs, the noise in each XIC is estimated using the approaches described by Wei et al. in MetSign software. Briefly, each XIC is first segmented into several peak groups based on the continuity of scan number, and the noise level is estimated by all XIC signals, except the regions potentia […]


Computational mass spectrometry for small molecules

J Cheminform
PMCID: 3648359
PMID: 23453222
DOI: 10.1186/1758-2946-5-12

[…] und. XCMS Online[] is the web-based version of the software. AStream[] enables the detection of outliers and redundant peaks by intensity correlation and retention time, as well as isotope detection. MetSign[] provides several bioinformatics tools for raw data deconvolution, metabolite putative assignment, peak list alignment, normalization, statistical significance tests, unsupervised pattern rec […]


Chronic Alcohol Exposure Disturbs Lipid Homeostasis at the Adipose Tissue Liver Axis in Mice: Analysis of Triacylglycerols Using High Resolution Mass Spectrometry in Combination with In Vivo Metabolite Deuterium Labeling

PLoS One
PMCID: 3566154
PMID: 23405143
DOI: 10.1371/journal.pone.0055382
call_split See protocol

[…] The experimental data were processed using software package MetSign . After peak alignment, a contrast based method was employed for normalization , . Both the Fisher’s exact test and the pairwise two-tail t-test were used to study the concentration change of […]

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MetSign institution(s)
Department of Chemistry, University of Louisville, KY, USA

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