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A key role in cell-mediated immunity is dedicated to the major histocompatibility complex (MHC) molecules that bind peptides for presentation on the cell surface. Several in silico methods capable of predicting peptide binding to MHC class I have been developed. The accuracy of these methods depends on the data available characterizing the binding specificity of the MHC molecules.
(Karosiene et al., 2012) NetMHCcons: a consensus method for the major histocompatibility complex class I predictions. Immunogenetics.