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MHCcluster specifications

Information


Unique identifier OMICS_05151
Name MHCcluster
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained Yes

Maintainer


  • person_outline Morten Nielsen <>

Publication for MHCcluster

MHCcluster in publications

 (8)
PMCID: 5610819
PMID: 29082265
DOI: 10.1155/2017/6412353

[…] 0 nm and ic50 < 100 nm, respectively, were selected for further analysis. the mhc class ii binding prediction tool predivac was also used to assess their affinity with hla_drb_1., furthermore, the mhccluster v2.0 server [] was used for the identification of cluster of mhc restricted allele with appropriate peptides to further strengthen our prediction. this is the additional crosscheck of the p […]

PMCID: 5561238
PMID: 28819312
DOI: 10.1038/s41598-017-08876-0

[…] carriers: or = 4.71, p = 0.06).figure 1 , similarities between binding specificities for the identified hla-c risk alleles (hla-c*04:01, -*05:01 and -*18:01) were examined with mhccluster (which groups hla molecules according to their peptide-binding specificity, ) and according to their characteristic motif across pockets (a-f) of the hla-c peptide-binding groove–. […]

PMCID: 5350106
PMID: 28360911
DOI: 10.3389/fimmu.2017.00282

[…] hp-35.0, and hp-63.0. furthermore, we also analyzed the functional diversities of 19 identified frequent sla class i molecules in this study and confirmed the existence of four supertypes using the mhccluster method. these results will be useful for studying the adaptive immune response and immunological phenotypic differences in pigs, screening potential t-cell epitopes, and further developing […]

PMCID: 5011678
PMID: 27317384
DOI: 10.1111/imm.12637

[…] recognition., in a previous study, alanine scanning mutagenesis demonstrated that lys59 was the c‐terminus anchor residue of the tp249–59 epitope but an n‐terminal anchor residue was not identified. mhccluster 2.0 predictions indicating that a serine (ser), alanine (ala) or threonine (thr) at p2 is the preferred n‐anchor residue for 2*01201 suggests that single‐alanine mutagenesis may […]

PMCID: 4911380
PMID: 27233953
DOI: 10.1007/s00251-016-0918-x

[…] the hla polymorphism and its immune function in a molecular evolutionary framework., in this study, we thus combine the use of the peptide-binding prediction tools described above (in particular mhccluster 2.0; thomsen et al. ) with an extensive analysis of molecular diversity in a large set of hla-typed population samples (6094 individuals from 46 populations worldwide, all of them tested […]


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MHCcluster institution(s)
Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Kemitorvet, Lyngby, Denmark

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