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MHCcluster specifications


Unique identifier OMICS_05151
Name MHCcluster
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained Yes


  • person_outline Morten Nielsen

Publication for MHCcluster

MHCcluster citations


Vaccinomics Approach for Designing Potential Peptide Vaccine by Targeting Shigella spp. Serine Protease Autotransporter Subfamily Protein SigA

J Immunol Res
PMCID: 5610819
PMID: 29082265
DOI: 10.1155/2017/6412353

[…] Furthermore, the MHCcluster v2.0 server [] was used for the identification of cluster of MHC restricted allele with appropriate peptides to further strengthen our prediction. This is the additional crosscheck of the p […]


Shared peptide binding of HLA Class I and II alleles associate with cutaneous nevirapine hypersensitivity and identify novel risk alleles

Sci Rep
PMCID: 5561238
PMID: 28819312
DOI: 10.1038/s41598-017-08876-0
call_split See protocol

[…] MHC cLuster NetMHCpan-2.8 (, NetMHCII Server (, IPD-IMGT/HLA (, Protein Data bank (PDB) ( […]


Swine Leukocyte Antigen Diversity in Canadian Specific Pathogen Free Yorkshire and Landrace Pigs

Front Immunol
PMCID: 5350106
PMID: 28360911
DOI: 10.3389/fimmu.2017.00282

[…] alyses of T-cell populations specific for peptide MHC tetramers, and by the web resource ICES index (–). In this process, the identification of peptides binding to SLA alleles is a critical step. The MHCcluster method just provides an important tool for functionally clustering MHC molecules based on their predicted binding specificities ().In this study, we characterized the alleles of five polymo […]


7th drug hypersensitivity meeting: part one

PMCID: 5009634
DOI: 10.1186/s13601-016-0121-z

[…] aterials and methods: HLA typing was performed on DNA from NCT00310843. Univariate and multivariate analyses stratified for race were performed according to HLA class I/II alleles, MHCcluster groups and key HLA peptide binding groove amino acids.Results: Examination of HLA allele peptide binding characteristics, together with structure of the B and F pockets in the peptide bindi […]


CD8 T‐cell responses against the immunodominant Theileria parva peptide Tp249–59 are composed of two distinct populations specific for overlapping 11‐mer and 10‐mer epitopes

PMCID: 5011678
PMID: 27317384
DOI: 10.1111/imm.12637

[…] In a previous study, alanine scanning mutagenesis demonstrated that Lys59 was the C‐terminus anchor residue of the Tp249–59 epitope but an N‐terminal anchor residue was not identified. MHccluster 2.0 predictions indicating that a serine (Ser), alanine (Ala) or threonine (Thr) at P2 is the preferred N‐anchor residue for 2*01201 suggests that single‐alanine mutagenesis may not have af […]


HLA class I molecular variation and peptide binding properties suggest a model of joint divergent asymmetric selection

PMCID: 4911380
PMID: 27233953
DOI: 10.1007/s00251-016-0918-x
call_split See protocol

[…] The method MHCcluster 2.0 (Thomsen et al. ), recently developed to cluster HLA molecules according to their peptide-binding specificities, was applied to estimate pairwise peptide-binding distances (PPBD) betwee […]

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MHCcluster institution(s)
Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Kemitorvet, Lyngby, Denmark

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