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MicroCosm Targets specifications


Unique identifier OMICS_00400
Name MicroCosm Targets
Alternative name miRBase Targets
Restrictions to use None
Maintained No

Publication for MicroCosm Targets

MicroCosm Targets citations


Resveratrol Improves Endothelial Progenitor Cell Function through miR 138 by Targeting Focal Adhesion Kinase (FAK) and Promotes Thrombus Resolution In Vivo

PMCID: 5822936
PMID: 29447140
DOI: 10.12659/MSM.906116

[…] transfected with FAK siRNA, RSV-induced EPCs exhibited decreased cell migration and angiogenesis when compared to the vehicle controls group ().Based on multiple databases (TargetScan, RNA22-HAS and MicroCosm Targets), FAK has been regarded as a potential target of miR-138 because of the presence of potential binding site located at 3′ UTR. To confirm that FAK is directly regulated by miR-138, we […]


Androgen receptor increases hematogenous metastasis yet decreases lymphatic metastasis of renal cell carcinoma

Nat Commun
PMCID: 5640635
PMID: 29030639
DOI: 10.1038/s41467-017-00701-6

[…] targeting the 3′ untranslated region (UTR) of mRNA. In contrast, they can also enhance gene expressions via targeting their 5′ promoter regions, . We then searched the online databases (DIANA miRGen, MicroCosm Targets, RNA22, and RegRNA2.0) and public literature to identify the potential miRNAs candidates (listed in Fig.  lower panel) that could enhance HIF2α/VEGF-A signal yet suppress VEGF-C and […]


Identification of an lncRNA miRNA mRNA interaction mechanism in breast cancer based on bioinformatic analysis

PMCID: 5647044
PMID: 28849135
DOI: 10.3892/mmr.2017.7304

[…] not be simultaneously recorded in the three prediction software algorithms, which may have influenced the selection of miRNAs. For example, a number of miRNAs are unable to be selected from PicTar or Microcosm Targets. The abundance of differentially-expressed genes means that the predictions in the present study may be refined further. In addition, the lncRNA-miRNA-mRNA regulatory mechanism analy […]


Regulation of Corticosteroidogenic Genes by MicroRNAs

PMCID: 5568613
PMID: 28852406
DOI: 10.1155/2017/2021903
call_split See protocol

[…] mapped and stored in the miRBase database (release 21, June 2014). Putative miRNA target sites in the 3′UTRs of corticosteroidogenic genes were identified by four commonly used prediction algorithms (MicroCosm Targets (v.5), microRNA.org (Nov 2010), miRviewer (June 2005), and TargetScan (v. 6.2)). […]


Activation of gga miR 155 by reticuloendotheliosis virus T strain and its contribution to transformation

PMCID: 5657028
PMID: 28113043
DOI: 10.1099/jgv.0.000718
call_split See protocol

[…] y Average (RMA) function within the Affy bioconductor package []. Affymetrix probes were linked to Ensembl genes using Ensembl (v70), and genes were linked to microRNA predicted targets data from the MicroCosm targets database [].For the naive prediction of miRNAs involved in the activation of genes from the mRNA expression data, the following analysis was performed: downregulated probes at 14 DPI […]


Genome Wide Detection of CNVs and Their Association with Meat Tenderness in Nelore Cattle

PLoS One
PMCID: 4922624
PMID: 27348523
DOI: 10.1371/journal.pone.0157711

[…] re screened for overlap with cattle QTLs from cattleQTLdb [], specific MT-QTLs in Nelore [], genes annotated in Biomart-Ensembl [], and 25,620 predicted target transcripts of 676 miRNAs listed in the Microcosm Targets database, version 5 [].Genes, which overlapped CNVRs, were subjected to an enrichment analysis with DAVID [] to identify metabolic pathways that are predominantly associated with gen […]

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MicroCosm Targets institution(s)
Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester, UK

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