A computational method to identify the pathways regulated by dysfunctional miRNAs. MiRSEA constructs a correlation profile of microRNA and pathways by the hypergeometric statistic test. The gene sets of pathways derived from the three public databases (Kyoto Encyclopedia of Genes and Genomes ('KEGG'); 'Reactome'; 'Biocarta') and the target gene sets of microRNA are provided by four databases ('TarBaseV6.0'; 'mir2Disease'; 'miRecords'; 'miRTarBase';). This package can quantify the change of correlation between microRNA for each pathway (or prior gene set) based on a microRNA expression data with cases and controls. MiRSEA uses the weighted Kolmogorov-Smirnov statistic to calculate an enrichment score (ES) of a microRNA set that co-regulate to a pathway, which reflects the degree to which a given pathway is associated with the specific phenotype. This package can provide the visualization of the results.