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Microsatellite instability identification software tools | High-throughput sequencing data analysis

Microsatellite instability identification software tools | High-throughput sequencing data analysis Microsatellite instability (MSI) is a form of hypermutation caused by defective DNA mismatch repair (MMR). MSI is characterized by widespread changes in the length of genomic mononucleotide repeats (e.g., AAAAA….) or microsatellites (e.g., GATAGATAGATA….), collectively termed simple repeats. MSI is also characterized by high rates of single-nucleotide-substitution (SNS) mutations. MSI can arise due to germ-line mutations in MMR genes, due to somatic mutations in MMR genes, or due to epigenetic inactivation of MMR genes.
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