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Phage-displayed random peptide libraries are powerful tools used to obtain mimotopes that are selected by binding to a given monoclonal antibody (mAb) in a similar way to the native epitope. These mimotopes can be considered as functional epitope mimics. Mimotope analysis based methods can predict not only linear but also conformational epitopes and this has been the focus of much research in recent years.
(Huang et al., 2008) Pep-3D-Search: a method for B-cell epitope prediction based on mimotope analysis. BMC Bioinformatics.