MiRcode

[…] . In 2015, Wang et al. identified functional RNA pairs by computing the Pearson correlation coefficients and p-values based on expression profiles []. Zhang et al. developed a competing network using miRcode, StarBase and miRTarBase in HCC, with a focus on the hub nodes of the network []. In 2017, Guo et al. assessed the joint predictive power of miRNAs and lncRNAs using miRNA and lncRNA expressio […]

[…] ir function []. In this way, lncRNAs can increase the amount of target mRNAs that are originally suppressed by miRNAs. To identify miRNAs that could be regulated by selected lncRNAs above (), we used miRcode, the database of miRNA target prediction []. To increase the reliability of the prediction, we utilized the expression data of miRNAs during VSMCs differentiation, which was obtained from GEO […]

[…] tion or competitive binding sites of miRNAs to reduce translation or degradation of mRNA. Among them, the function of a competitive endogenous RNA (ceRNA) is gaining notable attention. Both mirDB and mircode programs predicted that miR-24-3p may be a target of AC026166.2-001 (Fig. ). miRNAs can typically bind the 3′-UTR (untranslated region) of the mRNA and provide a biological function in the for […]

[…] ing miRNA in colon cancer, a ceRNA network graph was constructed based on above data and visualized using Cytoscape v3.5.0 (). We found that 9 DElncRNAs could interact with the 13 DEmiRNAs retrieving miRcode database ().We searched for targeted mRNAs based on 13 miRNAs using them iRanda, PicTar, TargetScan and miRDB database. The final targeted genes were selected, which most were included in all […]

[…] Disease) database [], the Human miRNA Disease Database (HMDD) [], and database of Differentially Expressed MiRNAs in human Cancers dbDEMC []. In addition, miRNA-target interaction databases including miRcode [] and miRanda [,,,,,,,], and ceRNA databases such as long non-coding competing endogenous database (lnCeDB) [] have been developed, which provide much useful information.In this study, we dev […]

[…] s and 11 normal samples. We used the WGCNA and protein–protein interaction (PPI) network to identify hub mRNAs from the differentially expressed mRNAs (DEmRNAs) profile. The databases, miRTarBase and miRcode, were used to screen the key differentially expressed lncRNAs (DElncRNAs) and differentially expressed micro RNAs (DEmiRNAs), as well as DEmiRNAs-DEmRNAs interactions. Hereafter, we constructe […]