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MiRComb | An R Package to Analyse miRNA-mRNA Interactions. Examples across Five Digestive Cancers

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An R package able to combine miRNA and mRNA expression data with hybridization information, in order to find potential miRNA-mRNA targets that are more reliable to occur in a specific physiological or disease context. MiRComb generates a list of results that can be the basis for developing multiple hypotheses to be experimentally tested in a wet lab. We have used as examples publicly available data from The Cancer Genome Atlas for different digestive cancers. The results highlight potential miRNA-mRNA interactomes of five digestive cancers and offer an unbiased view of miRComb functions.

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MiRComb forum

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MiRComb classification

MiRComb specifications

Unique identifier:
OMICS_12111
Interface:
Command line interface
Operating system:
Unix/Linux, Mac OS, Windows
Computer skills:
Advanced
Maintained:
Yes
Software type:
Package/Module
Restrictions to use:
None
Programming languages:
C++, R
Stability:
Stable

MiRComb distribution

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MiRComb support

Documentation

Maintainer

  • Meritxell Gironella <>

Credits

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Publications

Institution(s)

Bioinformatics Platform, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Barcelona, Catalonia, Spain; Gastrointestinal and Pancreatic Oncology Group, Hospital Clínic of Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Catalonia, Spain

Funding source(s)

The present work was supported by grants from Instituto de Salud Carlos III (PI13/02192; co-funded by FEDER-European Union) and from Fundación Científica de la Asociación Española contra el Cáncer (GCB13131592CAST).

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