Collects gene-centered background De Novo Germline Mutation Rates (DNMRs) obtained from different methods and population variation data. MirDNMR provides the following functions: (i) browse and search the background DNMRs of each gene predicted by four different methods, including GC content (DNMR-GC), sequence context (DNMR-SC), multiple factors (DNMR-MF) and local DNA methylation level (DNMR-DM); (ii) search variant frequencies in publicly available databases, including ExAC, ESP6500, UK10K, 1000G and dbSNP and (iii) investigate the DNM burden to prioritize candidate genes based on the four background DNMRs using three statistical methods.
Institute of Genomic Medicine, Wenzhou Medical University, Wenzhou, China; Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, China; Beijing Institutes of Life Science, Chinese Academy of Science, Beijing, China; The Eye Hospital of Wenzhou Medical University, The State Key Laboratory Cultivation Base and Key Laboratory of Vision Science, Ministry of Health, Wenzhou, China
mirDNMR funding source(s)
National Natural Science Foundation of China [31571357/C060702]; National Key Basic Research Program [2013CB967502]; National Natural Science Foundation of China