MicroRNA pharmacogenomic databases | Chemical informatics data analysis
The aim of pharmacogenomics is to identify individual differences in genome and transcriptome composition and their effect on drug efficacy. MicroRNAs (miRNAs) are short noncoding RNAs that negatively regulate expression of the majority of animal genes, including many genes involved in drug efficacy. Consequently, differences in the miRNA expression among individuals could be an important factor contributing to differential drug response.
Records 2925 relationships between 151 small molecules and 747 miRNAs in 17 species after manual curation from nearly 2000 articles. Each entry contains the detailed information about small molecules, miRNAs and evidences of their relationships, such as species, miRBase Accession number, DrugBank Accession number, PubChem Compound Identifier (CID), expression pattern of miRNA, experimental method, tissues or conditions for detection. SM2miR database has a user-friendly interface to retrieve by miRNA or small molecule. In addition, we offered a submission page. Thus, SM2miR provides a fairly comprehensive repository about the influences of small molecules on miRNA expression, which will promote the development of miRNA therapeutics.
Highlights interactions between miRNAs, genes and drugs in a specific pharmacogenomic context. Pharmaco miR contains features for parsing and data filtering and incorporate several sources focuses on miRNA targeting and pharmacogenomics. The application can be used: (i) for studying drug efficacy and toxicity (ii) formulating hypothesis dealing with miRNA pharmacogenomics; (iii) planning experiments and (iv) assisting in interpretation of results.