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miRStart specifications


Unique identifier OMICS_31136
Name miRStart
Alternative name MIcroRNA transcription Start sites
Restrictions to use None
Community driven No
Data access Browse
User data submission Not allowed
Maintained Yes


  • Primates
    • Homo sapiens

miRStart citations


Methods of MicroRNA Promoter Prediction and Transcription Factor Mediated Regulatory Network

Biomed Res Int
PMCID: 5474535
PMID: 28656148
DOI: 10.1155/2017/7049406

[…] f experimental TSS signals. In total, miRStart involves 940 human miRNAs. Among them, 352 miRNAs are inter-miRNAs, and 588 miRNAs are intra-miRNAs. The miRStart database is freely available at http://mirstart.mbc.nctu.edu.tw/.Panagiotis Alexiou et al. constructed miRGen database, providing the promoter positions of miRNA genes in human and mouse, and their regulation by TFs []. The data are suppor […]


MicroRNA 608 inhibits proliferation of bladder cancer via AKT/FOXO3a signaling pathway

Mol Cancer
PMCID: 5446711
PMID: 28549468
DOI: 10.1186/s12943-017-0664-1

[…] s miRNAs expression in cancer cells [, –]. In our study, we first predicted that the transcript start site (TSS) of miR-608 was possibly located 5456 bp upstream of the miR-608 locus by searching the miRStart database (http://mirstart.mbc.nctu.edu.tw/home.php) []. Then, we identified an explicit CpG island located near the TSS by using the CpG island searching program:MethPrimer (http://www.urogen […]


Whole Genome DNA Methylation Profiling Identifies Epigenetic Signatures of Uterine Carcinosarcoma12

PMCID: 5237802
PMID: 28088687
DOI: 10.1016/j.neo.2016.12.009

[…] st 5′ transcription start site (500 bp upstream and 500 bp downstream of TSS) of any RefSeq gene annotation. miRNA loci were downloaded from mirBASE. The microRNA gene cluster TSSs were download from mirStart (http://mirstart.mbc.nctu.edu.tw/). lincRNA loci were download from the Human lincRNA Catalog (http://www.broadinstitute.org/genome_bio/human_lincrnas/) . […]


miR 148a 3p represses proliferation and EMT by establishing regulatory circuits between ERBB3/AKT2/c myc and DNMT1 in bladder cancer

PMCID: 5261009
PMID: 27906180
DOI: 10.1038/cddis.2016.373

[…] se inhibitor 5-Aza-2′-deoxycytidine (5-Aza) significantly increased miR-148a-3p expression in the T24 and UM-UC-3 cell lines (). We predict the transcription start site (TSS) of miR-148a-3p using the miRStart database (http://mirstart.mbc.nctu.edu.tw/home.php). The results indicated the miR-148a-3p TSS was located 1188-bp upstream of its precursor (). We next used the CpG Island Searcher Program ( […]


Analysis of microRNA and Gene Expression Profiles in Multiple Sclerosis: Integrating Interaction Data to Uncover Regulatory Mechanisms

Sci Rep
PMCID: 5046091
PMID: 27694855
DOI: 10.1038/srep34512

[…] NAs and genes. We defined the promoter region as a 2 kbp sequence starting 1.5 kbp upstream of the transcription start site (TSS) and ending 0.5 kbp downstream of the TSS. We obtained miRNA TSS using miRStart (release July 21, 2010) and gene TSS using RefGene. We afterwards ran FIMO, a motif search tool of the MEME suite, together with HOCOMOCO, a database containing hand-curated transcription fac […]


Unveiling MYCN regulatory networks in neuroblastoma via integrative analysis of heterogeneous genomics data

PMCID: 5095001
PMID: 27167114
DOI: 10.18632/oncotarget.9202

[…] 26 up-regulated and 19 down-regulated miRNAs (Table ). Next, we examined whether these miRNAs were directly regulated by MYCN. Because the TSSs of the miRNAs were unclear, we used predicted TSSs from miRStart [] and PROmiRNA []. Therefore, the promoter of a miRNA was defined as the genomic region from 10 kb upstream of the predicted TSS to the start site of the miRNA precursor, and if an MYCN bind […]

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