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miRTrail specifications


Unique identifier OMICS_13363
Name miRTrail
Interface Web user interface
Restrictions to use None
Input data miRBase identifiers for miRNAs and GeneSymbol identifiers for the mRNAs.
Programming languages C++, PHP
Computer skills Basic
Stability Stable
Java web server
Maintained Yes


  • Primates
    • Homo sapiens
  • Rodents
    • Mus musculus
  • Vertebrates
    • Danio rerio



  • person_outline Andreas Keller

Publication for miRTrail

miRTrail citations


Integrative network based approach identifies key genetic elements in breast invasive carcinoma

BMC Genomics
PMCID: 4460623
PMID: 26040466
DOI: 10.1186/1471-2164-16-S5-S2

[…] fferentially expressed genes (mRNAs) involved three steps. First, for the set of differentially expressed miRNAs, which were either up- or down-regulated between the tumor and normal samples, we used miRTrail [] via MicroCosm Targets V5 (http://www.ebi.ac.uk/enright-srv/microcosm/htdocs/targets/v5/) to extract their target mRNAs (regulated genes) and overlapped them with the identified differentia […]


Comprehensive Reconstruction and Visualization of Non Coding Regulatory Networks in Human

Front Bioeng Biotechnol
PMCID: 4261811
PMID: 25540777
DOI: 10.3389/fbioe.2014.00069

[…] transcriptor factors. mirConnX (Huang et al., ), given a network of genes, transcriptor factors, and miRNAs, extends it with further TF and miRNA–gene intersections inferred by user expression data. miRTrail (Laczny et al., ) analyzes the role of miRNAs and genes deregulated in a disease by using a miRNA-gene networks and expression data.In this work, we have imported and integrated associations […]


A New Algorithm for Integrated Analysis of miRNA mRNA Interactions Based on Individual Classification Reveals Insights into Bladder Cancer

PLoS One
PMCID: 3663800
PMID: 23717626
DOI: 10.1371/journal.pone.0064543

[…] RNA-mRNA interaction predictions . Recently, methods and web-services for the integrated analysis of miRNA and mRNA expression data have been developed such as MAGIA , , MMIA , mirAct , miRConnX and miRTrail . GenMIR++ implements a Bayesian learning approach to identify differential miRNA-mRNA regulation , . HOCTAR calculates negative correlations between miRNA and mRNA expression . Other methods […]


A Systems Biology Approach to Characterize Biomarkers for Blood Stasis Syndrome of Unstable Angina Patients by Integrating MicroRNA and Messenger RNA Expression Profiling

PMCID: 3666437
PMID: 23762142
DOI: 10.1155/2013/510208

[…] 23 upregulated miRNAs and 408 downregulated mRNAs were uploaded into miRTrail. 4250 target mRNAs were predicted by microCosm. 115 mRNAs were found to be the overlap between the predicted target mRNAs and the actually downregulated mRNAs. 6 upregulated miRNAs were selec […]


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miRTrail institution(s)
Center for Bioinformatics, Saarland University, Saarbrücken, Germany; Department of Human Genetics, Saarland University, Homburg/Saar, Germany; Department of Computer Sciences, University of Tuebingen, Tübingen, Germany; Department of Internal Medicine III, University of Heidelberg, Heidelberg, Germany; Siemens Healthcare, Erlangen, Germany
miRTrail funding source(s)
This work has been funded by DFG Priority Program SPP 1335: LE 952/3- 1, DFG LE 952/5-1, and by DFG Me 917/20-1.

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