MIRU-VNTRplus statistics

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MIRU-VNTRplus specifications


Unique identifier OMICS_24291
Name MIRU-VNTRplus
Alternative name Mycobacterial Interspersed Repetitive-Unit-Variable-Number Tandem-Repeat plus
Software type Application/Script
Interface Web user interface
Restrictions to use None
Input data A single user strain.
Input format FASTA
Computer skills Basic
Stability Stable
Maintained Yes


  • person_outline Thomas Weniger

Publications for Mycobacterial Interspersed Repetitive-Unit-Variable-Number Tandem-Repeat plus

MIRU-VNTRplus citations


Genetic diversity of drug and multidrug resistant Mycobacterium tuberculosis circulating in Veracruz, Mexico

PLoS One
PMCID: 5854261
PMID: 29543819
DOI: 10.1371/journal.pone.0193626
call_split See protocol

[…] Genotypes were expressed as numerical codes representing the number of MIRU-VNTR for each locus. Lineages were individually identified using the similarity search module [] of the database MIRU-VNTRplus (http://www.miru-vntrplus.org/MIRU/index.faces)[].The tree polar arrangement was realized by the FigTree program (Tree Figure Drawing Tool Version 1.4.3. http://tree.bio.ed.ac.uk/softwar […]


Molecular Characterization of Mycobacterium avium subsp. hominissuis of Two Groups of Lymph Nodes, Being Intradermal Tuberculin or Interferon Gamma Test Positive and Negative, Isolated from Swiss Cattle at Slaughter

PMCID: 5844927
PMID: 29556502
DOI: 10.3389/fvets.2018.00032

[…] Genetic strain lineages were predicted using online tools available from MIRU-VNTRplus website (). A dendrogram based on 20 VNTR loci was generated using the unweighted pair group method using arithmetic averages (UPGMA) algorithm.Variable number of tandem repeat data from […]


Genetic diversity and potential routes of transmission of Mycobacterium bovis in Mozambique

PLoS Negl Trop Dis
PMCID: 5772998
PMID: 29346413
DOI: 10.1371/journal.pntd.0006147
call_split See protocol

[…] In order to evaluate relatedness of the spoligotype and VNTR patterns of the different samples we generated a dendogram using the UPGMA algorithm using the tool provided on the site http://www.miru-vntrplus.org/. The spoligotype patterns of the respective isolates were entered into the Mbovis.org database. In this database each unique spoligotype pattern is named by 'SB' followed by a four […]


Convergent evolution and topologically disruptive polymorphisms among multidrug resistant tuberculosis in Peru

PLoS One
PMCID: 5744980
PMID: 29281674
DOI: 10.1371/journal.pone.0189838

[…] onfirmed using principal component analysis. Clades were named using the corresponding MIRU-VNTR and spoligotype independently by the Institut Pasteur Guadeloupe according to published protocols (www.miru-vntrplus.org and www.pasteur-guadeloupe.fr:8081/SITVIT_ONLINE) []. Ancestral state reconstruction was undertaken using maximum parsimony, likelihood and Bayesian approaches. […]


Molecular analysis of pyrazinamide resistance in Mycobacterium tuberculosis in Vietnam highlights the high rate of pyrazinamide resistance associated mutations in clinical isolates

PMCID: 5658769
PMID: 29018250
DOI: 10.1038/emi.2017.73

[…] sed to investigate genotypic diversity and clustering in the selected M. tuberculosis samples. A neighbor-joining based phylogenetic tree was built from DSW distances using MIRU-VNTR plus (http://www.miru-vntrplus.org/) (). Isolates were classified as ‘unknown’ when their spoligotypes could not be identified in the SITVITWEB database and when the 24-MIRU-VNTR typing could not classify them into a […]


Evolutionary pathway analysis and unified classification of East Asian lineage of Mycobacterium tuberculosis

Sci Rep
PMCID: 5569047
PMID: 28835627
DOI: 10.1038/s41598-017-10018-5

[…] o the standard spoligotyping scheme). The Beijing genotype can also be identified based on phylogenetic analysis of the high-resolution 24 VNTR loci within the context of known reference strains (www.MIRU-VNTRplus.org).The Beijing family was long believed to be a homogeneous group of strains, first of all based on the similarity of their IS6110-RFLP profiles (see representative examples in ref. ), […]


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MIRU-VNTRplus institution(s)
Department of Periodontology, University Hospital Munster, Munster, Germany; Molecular Mycobacteriology, Forschungszentrum Borstel, Borstel, Germany; CIIL – Center for Infection and Immunity of Lille INSERM U 1019, CNRS UMR 8204 Univ Lille Nord de France, Institut Pasteur de Lille, France
MIRU-VNTRplus funding source(s)
Supported by German Federal Ministry of Education and Research in the framework of the Network Zoonoses (grant number 01KI07124) and PathoGenomikPlus Network (grant number 0313801J).

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