MIRZA statistics

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Associated diseases

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MIRZA specifications

Information


Unique identifier OMICS_05259
Name MIRZA
Software type Package/Module
Interface Command line interface
Restrictions to use None
Input data mRNA fragments and miRNA sequences
Input format FASTA
Operating system Unix/Linux
Programming languages C, C++, Fortran
Computer skills Advanced
Stability Stable
Maintained No

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Publication for MIRZA

MIRZA in publications

 (4)
PMCID: 5131338
PMID: 27905558
DOI: 10.1038/srep36766

[…] supported targets of mir-34 using argonaute crosslinking and immunoprecipitation (ago-clip) data generated by grosswendt et al., in combination with mirna target predictions calculated by mirza software. in total, we identified 1304 genes with a mirza score above 100, of which 214 are also supported by ago-clip data (). the daf-16 gene was among the top 20 targets that showed […]

PMCID: 4532895
PMID: 26267216
DOI: 10.7554/eLife.05005.028

[…] reported conservation signal might occur for the same reason that artificial sirnas tend to target conserved regions of 3′ utrs ()., next, we evaluated the response of non-canonical sites modeled by mirza, an algorithm that utilizes clip data in conjunction with a biophysical model to predict target sites (). as noted by others (), the definition of non-canonical mirza sites was more expansive […]

PMCID: 4615376
PMID: 25485975
DOI: 10.4161/19491034.2014.990864

[…] sites for both mir-206-3p and mir-206-5p in the 3′ utr of igf2 mrna. (the terminology “strong binding sites” as used here derives from the rigorous themodynamic parameters incorporated into the mirza software.) in addition, strong binding sites in the 3′ utr of igf2 mrna were also predicted for each of the other 4 nucleolus-associated micrornas: mir-351 (), mir-494 and mir-340 () […]

PMCID: 4053862
PMID: 24460822
DOI: 10.1186/gb4151

[…] of seed-type mir-92a targets, and thus the significance of these non-canonical interactions remains to be determined. nonetheless, as more clash datasets emerge, it will be interesting to apply the mirza inference procedure described in khorshid et al. [] to clash data to infer mirna-specific modes of interaction with the targets. the mirza approach can be further adapted to infer mirna-target […]


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MIRZA institution(s)
Biozentrum, University of Basel, Basel, Switzerland; Swiss Institute of Bioinformatics, Basel, Switzerland
MIRZA funding source(s)
This project was supported by Swiss National Science Foundation ProDoc grant PDFMP3_123123 and by Swiss National Science Foundation grant 31003A_127307.

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