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MiSTIC specifications

Information


Unique identifier OMICS_18167
Name MiSTIC
Alternative name Minimum Spanning Trees Inferred Clustering
Interface Web user interface
Restrictions to use None
Input data A dataset, a gene.
Input format ENTREZ GENE, SYMBOL
Computer skills Basic
Stability Stable
Maintained Yes

Maintainer


  • person_outline Guy Sauvageau <>

Information


Unique identifier OMICS_18167
Name MiSTIC
Alternative name Minimum Spanning Trees Inferred Clustering
Software type Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux
Computer skills Advanced
Stability Stable
Maintained Yes

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Maintainer


  • person_outline Guy Sauvageau <>

Publication for Minimum Spanning Trees Inferred Clustering

MiSTIC in publications

 (38)
PMCID: 5932063
PMID: 29720613
DOI: 10.1038/s41598-018-25329-4

[…] called the kullback–leibler (kl) divergence score metric was used to evaluate sequence conservation in the hsp90 chaperones (fig. ). the kl conservation score was calculated in the framework of mistic approach using multiple sequence alignment (msa) profile generated using hidden markov models in the pfam database. to analyze domain-based distribution of ptm sites in the hsp90 proteins, […]

PMCID: 5733091
PMID: 29312953
DOI: 10.3389/fmolb.2017.00085

[…] the reference sequence and structure were set as opsd_bovin with the pdb code 1 μ19. the conservation and co-evolutionary analyses on the rhodopsin-like family of sequences were carried out with the mistic server (http://mistic.leloir.org.ar/index.php). the mutual information score as implemented in mistic is calculated between pairs of columns in the msa. the frequency for each amino acid pair […]

PMCID: 5654724
PMID: 29065306
DOI: 10.1016/j.devcel.2017.08.020

[…] were introduced by quikchange., to express m. musculus ndc1 and a c-terminal fragment of x. laevis gp210 () in bacteria, the respective coding sequences were cloned into pet28a with an n-terminal mistic (membrane-integrating sequence for translation of integral membrane protein constructs) sequence to enhance expression in e. coli (). for ndc1, a synthetic dna, codon-optimized for expression […]

PMCID: 5709755
PMID: 28960191
DOI: 10.1038/bcj.2017.86

[…] of survival curves were performed using the kaplan–meier method and log-rank test, and analysis of patient rna-seq data was performed using a welch two-sample t-test in r (version 3.3.1). mistic was used to perform single gene and pairwise correlation analyses and visualise leucegene rna-seq data. other statistical analyses and visualisation of data were performed with excel […]

PMCID: 5625587
PMID: 28953320
DOI: 10.7448/IAS.20.6.22253

[…] fd benjelloun 1,2; h quillay1,3; c cannou1,2; r marlin1,2,4; y madec5; h fernandez6; f chrétien7; r le grand2,4; f barré-sinoussi8; m-t nugeyre1,2,4 and e menu1,2,4 , 1institut pasteur, mistic group – virology, paris, france. 2cea, u1184 imva-idmit, fontenay aux roses, france. 3university paris diderot, paris, france. 4vaccine research institute (vri), creteil, france. 5institut […]

MiSTIC institution(s)
The Leucegene project, Université de Montréal, Montréal, Canada; Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montréal, Canada; Computer science and operation research, Universite de Montréal, Montréal, Canada; Division of Molecular Medicine, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia; Division of Hematology, Maisonneuve-Rosemont Hospital, Montréal, Canada; Leukemia Cell Bank of Quebec, Maisonneuve-Rosemont Hospital, Montréal, Canada; Department of Medicine, Faculty of Medicine, Universite de Montréal, Montréal, Canada; Department of Biochemistry, Université de Montréal, Montréal, Canada; Centre de Recherche du Centre Hospitalier Universitaire de l’Université de Montréal, Montréal, Canada
MiSTIC funding source(s)
Supported by Genome Quebec; Terry Fox Foundation; Canada Research Chair in the Molecular Genetics of Stem Cells; Cancer Research Network of the Fonds de Recherche du Quebec-Santé; Australian Government National Health and Medical Research Council [Independent Research Institute Infrastructure Support Scheme; program grant 1016647]; Canadian Cancer Society Research Institute [703961]; Canadian Imperial Bank of Commerce breast cancer research chair at Université de Montréal.

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