MISTIC pipeline

MISTIC specifications


Unique identifier OMICS_08231
Alternative names Mutual Information Server to Infer Coevolution, MISTIC2
Interface Web user interface
Restrictions to use None
Input data Multiple sequence alignment (Fasta, Nexus, PIR, ClustalW or Phylip format) or PFAM id
Computer skills Basic
Stability Stable
Maintained Yes


  • person_outline Cristina Marino-Buslje <>

Publications for Mutual Information Server to Infer Coevolution

MISTIC citation

PMCID: 5932063

[…] which reflects the extent to which knowing the amino acid at one position can predict the amino acid identity at the other position. mi was calculated between pairs of columns in the msa using mistic approach46,85,86. mi is a nonlinear statistic that measures the information between two random and discrete variables. given that any two positions in the msa can be considered random […]

MISTIC institution(s)
Bioinformatics Unit, FundaciĆ³n Instituto Leloir, Av Patricias Argentinas, Buenos Aires, Argentina

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