Identifies potential pathway regulation by (i) an enrichment analysis of miRNA targets genes and (ii) by using a proximity score to evaluate the functional role of miRNAs in biological pathways by their network proximity. miTALOS provides novel features that accomplish a substantial support to systematically infer regulation of signaling pathways mediated by miRNAs.
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Institute for Bioinformatics and Systems Biology, Helmholtz Zentrum München, 85764 Neuherberg, Germany; Institute for Mathematical Sciences, Technische Universität München, 85747 Garching, Germany
This work was supported by the Federal Ministry of Education and Research (BMBF) and its MedSys initiative (projects “LungSys”), the Helmholtz Alliance on Systems Biology (project “CoReNe”), and by the German Science Foundation (DFG) within the SPP 1395 (InKoMBio).