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Identifies potential pathway regulation by (i) an enrichment analysis of miRNA targets genes and (ii) by using a proximity score to evaluate the functional role of miRNAs in biological pathways by their network proximity. miTALOS provides novel features that accomplish a substantial support to systematically infer regulation of signaling pathways mediated by miRNAs.

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  • Andreas Kowarsch <andreas.kowarsch at helmholtz-muenchen.de>


Institute for Bioinformatics and Systems Biology, Helmholtz Zentrum München, 85764 Neuherberg, Germany; Institute for Mathematical Sciences, Technische Universität München, 85747 Garching, Germany

Funding source(s)

This work was supported by the Federal Ministry of Education and Research (BMBF) and its MedSys initiative (projects “LungSys”), the Helmholtz Alliance on Systems Biology (project “CoReNe”), and by the German Science Foundation (DFG) within the SPP 1395 (InKoMBio).

  • (Kowarsch et al., 2011) miTALOS: analyzing the tissue-specific regulation of signaling pathways by human and mouse microRNAs. Rna.
    PMID: 21441347
  • Animals
    • Homo sapiens
    • Mus musculus
  • (Akhtar et al., 2016) Bioinformatic tools for microRNA dissection. Nucleic acids research.
    PMID: 26578605

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