MitoProteome

[…] ial pre-sequences and the cleavage sites of MPP were predicted by Gavel’s consensus patterns search in the PSORTII program (http://psort.hgc.jp/form2.html) [,] and MitoProt II [], using the T. brucei mitoproteome dataset []. Proteins with predicted pre-sequences were further analyzed for the MIP cleavage motif (F/L/I)XX(T/S/G)XXXX [] within the octapeptide which immediately follows the MPP cleavag […]

[…] ia, to form enzyme complexes of the electron transport chain, Kreb cycle, and other mitochondrial processes (Wallace, ; Sue and Schon, ; Lescuyer et al., ; Taylor et al., ; Chevallet et al., ). Thus, mitoproteome expression is highly dependent on nuclear transcription and protein translation taking place on cytoplasmic ribosomes. Based on a review by Wahl et al. (), the global expression datasets […]

[…] t (FDR Q-value < 0.0001) based on the presence of DES, KRT3, KRT4, KRT5, KRT15, KRT75, LMNB2, DSP, SYNM and JUP). The down-regulated list received no significant formal enrichment by this approachThe mitoproteome of 228 proteins was significantly skewed towards the High FE birds, indicating a higher tissue mitochondria content (binomial probability P < 0.00001; ). These findings are consistent wit […]

[…] not differentially expressed between samples (). Ontological analysis of these proteins for biological process and molecular function is shown in . The spectra were subsequently screened against the Mitoproteome database on 10th and 19th June 2013 which identified some 288 mitochondrial proteins, representing approximately 40% of the database annotated mitochondrial proteome. Of these 288 protein […]

[…] tion of other RNA types in this organelle (). Therefore, we asked whether there is an additional ribonuclease in the MBL protein family in human mitochondria. The study was initiated by searching the Mitoproteome database (,) to identify putative mitochondrial MBL proteins with predicted ribonuclease activity. The search revealed LACTB2, a nuclear-encoded protein with an unknown function, that is […]

[…] 70 have been identified, respectively. According to the Mitoprot and TargetP programs, their N termini are predicted to carry an mt import signal, and the respective proteins were indeed found in the mitoproteome of T. brucei (). […]