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MMpl specifications


Unique identifier OMICS_22867
Name MMpl
Alternative name Matrix Metalloproteinases Inhibitors
Restrictions to use None
Database management system MySQL
Community driven No
Data access File download, Browse
User data submission Not allowed
Maintained Yes


  • person_outline Subramanian Venkatesan
  • person_outline Subrumanian Venkatesan

Publication for Matrix Metalloproteinases Inhibitors

MMpl citations


Parapatric genetic divergence among deep evolutionary lineages in the Mediterranean green crab, Carcinus aestuarii (Brachyura, Portunoidea, Carcinidae), accounts for a sharp phylogeographic break in the Eastern Mediterranean

BMC Evol Biol
PMCID: 5896055
PMID: 29642852
DOI: 10.1186/s12862-018-1167-4

[…] ario. Values of 2ln (BF) > 10 were considered as very strong evidence for a given model to be more likely than another []. As the Bayes factors indicated a much better fit for the strict clock model (MMPL = − 9484.4) than for a relaxed clock model (MMPL = − 9984.3) (2 ln(BF) =12.428), the final analyses were carried out with a strict molecular clock, and assuming the generalised time reversible (G […]


Use of Soluble Extracellular Regions of MmpL (SERoM) as Vaccines for Tuberculosis

Sci Rep
PMCID: 5884834
PMID: 29618733
DOI: 10.1038/s41598-018-23893-3

[…] Synthetic MmpL peptide regions were designed using TMHMM. The coding regions for the two large loops found in RND proteins as predicted by TMHMM were provided to Genescript (New Jersey, USA) for synthesis and c […]


Molecular and genomic features of Mycobacterium bovis strain 1595 isolated from South Korean cattle

PMCID: 5583421
PMID: 28385004
DOI: 10.4142/jvs.2017.18.S1.333

[…] own that mycobacterial virulence lipids such as trehalose dimycolate/monomycolate, phthiocerol dimycocerosate, and sulfolipids, and the protein machinery such as mycobacterial membrane protein large (MmpL) and mammalian cell entry protein required for their export are intercalated in the cell wall []. Mycobacterial cells have a unique component containing a high proportion of lipids in their envel […]


Screening of TB Actives for Activity against Nontuberculous Mycobacteria Delivers High Hit Rates

Front Microbiol
PMCID: 5559473
PMID: 28861054
DOI: 10.3389/fmicb.2017.01539

[…] that protein synthesis is an attractive target for NTM.Two hits, MMV687146 (an indole-2-carboxamide) and MMV688846 (a piperdinol), have been reported to target the trehalose monomycolate transporter MmpL3 and disrupt mycolic acid synthesis in mycobacteria (Lun et al., ; Dupont et al., ). In recent years, with the discovery of several new TB drug leads, such as SQ109, BM212 and AU1235, MmpL3 has b […]


Unraveling the Microbial Interactions and Metabolic Potentials in Pre and Post treated Sludge from a Wastewater Treatment Plant Using Metagenomic Studies

Front Microbiol
PMCID: 5515832
PMID: 28769920
DOI: 10.3389/fmicb.2017.01382

[…] sent in RS indirectly reveals the current health status of the local population (; ). The abundance of Mycobacterium virulence operons and regulons, chaperones required for the pathogenesis (Hsp225), Mmpl6 membrane protein cluster and multidrug resistance efflux pumps uncover the prevalence of infectious diseases in the local population.Moreover, iron acquisition by pathogens is related to bacteri […]


The putative drug efflux systems of the Bacillus cereus group

PLoS One
PMCID: 5417439
PMID: 28472044
DOI: 10.1371/journal.pone.0176188

[…] (HAE2) family (TCDB 2.A.6.5) clade (). Most of the characterised pumps in this family transport lipids or cell wall components. With respect to proteins listed in the TCDB, BC1291 is most related to MmpL3 and MmpL11 from Mycobacterium tuberculosis, which transport mycobacterial specific cell wall components (). The YdfJ system encoded in B. subtilis is also a member of the HAE2 family. A deletion […]

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MMpl institution(s)
Chemical Laboratory, Council of Scientific and Industrial Research-Central Leather Research Institute, Chennai, India; Academy of Scientific and Innovative Research (AcSIR), New Delhi, India; Department of Biotechnology, Indian Institute of Technology Guwahati, Guwahati, Assam, India
MMpl funding source(s)
Supported by the Council of Scientific and Industrial Research (CSIR), (GENESIS, BSC0121 and OSDD projects) and Department of Biotechnology (DBT) NER-Twinning project (No. BT/ 272/NE/TBP/2011), New Delhi, India.

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