Interprets tandem mass spectra of peptides with multiple post-translational modifications (PTMs). MODi is a convenient method that consists of five stages: peak selection, tag discovery, database search, tag chain generation and PTM identification. This method adopts a hybrid approach that combines de novo sequencing with database searching. It assumes that the number of candidate proteins is limited to 20 or less, and focuses on finding PTMs in tandem mass spectra.
Research Center for Computer Technology, Hanyang University, Seoul, Korea; Department of Mechanical and Information Engineering, University of Seoul, Seoul, Korea; School of Computer Science and Engineering, Seoul National University, Seoul, Korea; College of Information and Communications, Hanyang University, Seoul, Korea; Center for Cell Signaling Research, Division of Molecular Life Sciences and College of Pharmacy, Ewha Womans University, Seoul, Korea; Functional Proteomics Center, Korea Institute of Science and Technology, Seoul, Korea; Lab Frontier Co. Ltd, Seoul, Korea
MODi funding source(s)
Supported by 21C Frontier Functional Proteomics Project from Korean Ministry of Science and Technology (FPR05A2-340 and FPR05A2-480) and through the Center for Cell Signaling Research (CCSR) at Ewha Womans University.