MoFi specifications

Information


Unique identifier OMICS_28486
Name MoFi
Alternative name modification finder
Software type Application/Script
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux, Windows
Programming languages C++, Python
Computer skills Advanced
Version 1.1
Stability Stable
Requirements
NumPy, pandas, matplotlib, PyQt5, xlrd, xlsxwriter, Sphinx
Maintained Yes

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Versioning


No version available

Maintainer


  • person_outline Christian Huber

Publication for modification finder

MoFi citation

library_books

Native mass spectrometry combined with enzymatic dissection unravels glycoform heterogeneity of biopharmaceuticals

2018
Nat Commun
PMCID: 5928108
PMID: 29712889
DOI: 10.1038/s41467-018-04061-7

[…] TNFR revealed that core-fucosylated N-glycans lacking galactose predominate on the Fc domain, whereas on TNFR most N-glycans are galactosylated and structures lacking core fucose occur (Fig. ). Using MoFi, systematic integration of data obtained for O-glycoforms, N-glycopeptides as well as N-glycoforms of TNFR and Fc domains, enabled annotation of masses up to the level of desialylated Etanercept. […]

MoFi institution(s)
Department of Biosciences, Bioanalytical Research Labs, University of Salzburg, Salzburg, Austria; Christian Doppler Laboratory for Innovative Tools for Biosimilar Characterization, University of Salzburg, Salzburg, Austria
MoFi funding source(s)
Supported by the Austrian Federal Ministry of Science, Research, and Economy and by a Start-up Grant of the State of Salzburg.

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