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MEGA-MD | Molecular evolutionary genetics analysis software with mutational diagnosis of amino acid variation

A suite of tools developed to forecast the deleteriousness of nsSNVs using multiple methods and to explore nsSNVs in the context of the variability permitted in the long-term evolution of the affected position. In its graphical interface for use on desktops, it enables interactive computational diagnosis and evolutionary exploration of nsSNVs. The MEGA-MD suite intends to serve the needs for conducting low- and high-throughput analysis of nsSNVs in diverse applications.

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MEGA-MD classification

  • Animals
    • Homo sapiens

MEGA-MD specifications

Unique identifier:
Software type:
Restrictions to use:
Academic or non-commercial use
Computer skills:
Molecular Evolutionary Genetics Analysis software with Mutational Diagnosis
Graphical user interface
Operating system:

MEGA-MD distribution


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MEGA-MD support


  • Sudhir Kumar <>


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Center for Evolutionary Medicine and Informatics, Biodesign Institute, Arizona State University (ASU), Tempe, AZ, USA

Funding source(s)

US National Institutes of Health (LM010730-03 and HG002096-12)

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