Analyzes transcriptomic data from cellularly homogeneous sample to define functional heterogeneity. MPH method quantifies the functional heterogeneity of homogeneous cell population based on transcriptomic data. This tool combines molecular process and proportions with an approximation of the differences in in gene expression levels for cells. This algorithm employs a non-negative matrix factorization (NMF) method.
Institute of Informatics, University of Warsaw, Warsaw, Poland; Faculty of Biology, University of Warsaw, Warsaw, Poland; College of Inter-Faculty Individual Studies in Mathematics and Natural Sciences, University of Warsaw, Warsaw, Poland; Bioinformatics Laboratory, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
MPH method funding source(s)
Supported by the Polish National Science Centre Grants nos. 2015/19/N/ST6/03013, 2016/21/N/ST6/01507, and 2014/12/W/ST5/00592; through the European Social Fund, Contract no. UDA-POKL.04.01.01-00-072/09-00; Biocentrum-Ochota project (POIG.02.03.00-00-003/09); and funds of Bioinformatics Laboratory, IMDiK PAS (Z-526, #21).