bookmark Tomtom Compares one or more motifs against a database of known motifs. Tomtom ranks the motifs in the database and produces an alignment for each significant match. The tool is part of the MEME Suite online platform. It not only provides a numeric score for the match between two motifs, but also an estimate of the statistical significance of the score. Tomtom only supports DNA motifs. To compute the scores, the tool needs to know the frequencies of the letters of the sequence alphabet in the database being searched.