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MPEx specifications


Unique identifier OMICS_23466
Name MPEx
Alternative name Membrane Protein Explorer
Software type Application/Script
Interface Graphical user interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Programming languages Java
Computer skills Medium
Stability Stable
Maintained Yes




No version available


Additional information

Publication for Membrane Protein Explorer

MPEx citations


Structural properties of apolipoprotein A I mimetic peptides that promote ABCA1 dependent cholesterol efflux

Sci Rep
PMCID: 5811490
PMID: 29440748
DOI: 10.1038/s41598-018-20965-2
call_split See protocol

[…] ividing the equilibrated time series into 10 blocks. The error bar equals the standard deviation of means of blocks divided by 10.Hydrophobic moments and hydrophobicities (Table ) were obtained using MPEx v. 3.2.14 with the Wimley-White hydrophobicity scale based on POPC- water interface. The mean hydrophobic moment is calculated as the vectorial sum of all the hydrophobicity indices, divided by t […]


Membrane Topology and Heme Binding of the Histidine Kinases HrrS and ChrS in Corynebacterium glutamicum

Front Microbiol
PMCID: 5812335
PMID: 29479345
DOI: 10.3389/fmicb.2018.00183

[…] d on PhoA/LacZ fusions. For the prediction of membrane spanning α-helices different analysis tools were applied, including TopPredII (), TMPred (), Hmmtop (), Minnou polyview (), CBS TMHMM (), DAS () Mpex (), TOPCONS (), and Phobius ().As indicated in Supplementary Table , five out of nine programs suggested five transmembrane helices (TMHs) for ChrS, whereas three tools predicted six TMHs. The ou […]


Membrane insertion of the BAX core, but not latch domain, drives apoptotic pore formation

Sci Rep
PMCID: 5701199
PMID: 29176554
DOI: 10.1038/s41598-017-16384-4
call_split See protocol

[…] BAX and BCLXL structural representations were generated by Pymol. Main biophysical characteristics of BAX-derived peptides were determined by MPEx and Heliquest. MC simulations of the interaction of peptide molecules with MOM-like membranes were performed using the MCPep web server. The web server´s output includes the free energy of peptid […]


Cell surface Thomsen Friedenreich proteome profiling of metastatic prostate cancer cells reveals potential link with cancer stem cell like phenotype

PMCID: 5716753
PMID: 29228713
DOI: 10.18632/oncotarget.21985

[…] The consensus transmembrane topology prediction strategy was adopted and three transmembrane prediction software tools including TMHMM 2.0 (, MPEx 3.2 and TopPred 0.01 ( were used to identify the transmembrane proteins (see for detail). […]


Structure formation during translocon unassisted co translational membrane protein folding

Sci Rep
PMCID: 5556060
PMID: 28808343
DOI: 10.1038/s41598-017-08522-9

[…] rliest folding stages (<13 minutes) suggesting that several folding, and misfolding, pathways are occurring co-translationally for both proteins.Hydropathy plots were produced for GlpG and DsbB using MPEx (Fig. ). MPEx is comprised of two analyses; the translocon TM analysis, which analyses the TM transfer free energetics based on translocon-mediated TM helix assembly, and the Octanol-Interfacial […]


A Motif in the F Homomorph of Rabbit Haemorrhagic Disease Virus Polymerase Is Important for the Subcellular Localisation of the Protein and Its Ability to Induce Redistribution of Golgi Membranes

PMCID: 5580459
PMID: 28763035
DOI: 10.3390/v9080202
call_split See protocol

[…] Kyte–Doolittle hydrophobicity plots [], MPex [], TM Finder [] and TMpred [] prediction programs were used for identification of a putative interacting motif.Graphs were generated using GraphPad Prism software (La Jolla, CA, USA; http://www. […]


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MPEx institution(s)
Department of Physiology and Biophysics, Center for Biomembrane Systems, University of California, Irvine, CA, USA; Department of Chemistry and Biochemistry, California State University, San Marcos, San Marcos, CA, USA; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, USA

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